Amputation induced Reactive Oxygen Species regulate tissue regeneration in Clinotarsus curtipes tadpoles

Abstract

Regeneration is the ability of an organism to repair a wound which is partially destroyed tissue of animal’s body or the damage involving the loss of an organ or the larger part of the body. Understanding the molecular mechanisms that promote tissue regeneration is necessary for advancements in regenerative medicine. Amphibian tadpoles’ residents of aquatic systems, species Clinotarsus curtipes have the ability to regenerate their tails after amputation within 2 weeks effectively. Tail amputation induces a massive recruitment of inflammatory cells to the site of injury and produce high levels of ROS. Traditionally, ROS have been thought to have a negative impact on cells. But in this case they seemed to be having a positive impact on tail re-growth. Lowering levels of ROS impairs tail regeneration while sustained increased ROS are essential for downstream signaling pathway for proper tail regeneration. The findings demonstrate that injury-induced ROS production is an important regulator of tissue regeneration.