Formulation, Development and Evaluation of Bilayer Tablet of Flurbiprofen
DOI:
https://doi.org//10.32628/IJSRST196130Keywords:
Sodium Starch Glycolate, HPMC K15, Wet Granulation Method.Abstract
In the Study of Formulation of Bilayer Tablet of Flurbiprofen the Following Materials Using sodium starch glycolate as immediate release and HPMC K15 in different ratios as release retardant materials using a wet granulation method. All tablets exhibited good physical properties with Respect to appearance, content uniformity, hardness, weight variation and Invitro dissolution data show at increasing proportions of sodium starch glycolate for immediate release whereas HPMC K15sustaineddrugreleaserate. The bilayer tablets showed an initial release of drug In about1hr, then sustaining the release for 12h, The kinetic analysis of dissolution data showed that release was observe din these tablets. When data was fitted to the Higuchi model. Bilayer tablets of flurbiprofen can be successfully formulated Using sodium starch glycolate and HPMC K15 in different ratios as release retardant materials employing a wet granulation method.
References
- Mukho padhyay S, Goswami L, Satheesh Madhav Nv, U padhyaya K. Formulation and evaluation of floating bioadhesive tablets of Ciprofloxacin hydrochloride by direct compression technique. Int J Pharm and Pharm Sci. 2010; 2(3): 113-15.
- Derle D, Joshi O, Pawar A, Patel J, Jagadale A. Formulation and evaluation of buccoadhesive bi-layer tablet of propranolol hydrochloride. Int J Pharm and Pharm Sci.2009; 1(1): 206-12.
- Allen, Loydv: Ansel’s pharmaceutical dosage form and drug delivery systems by loyd V. allen edition 2014.
- USP37NF32 United states pharmacopoeia: United States pharmacopial convention 2014.
- Banu H and Sahariar M R. Formulation development of bi-layer acetaminophen tablets for extended drug release. JChem Pharm Res.2011; 3(6):348-360.
- Solanki P D. Formulation evaluation and optimization of bilayer floating tablet of repaglinide and glipizide. Inter J Pharm Rese Schoc.2012; 1(3):123-134.
- Sadhana R S and Vidya M M. Development and evaluation of bilayer floating tablets of diltiazem hcl.Inter J Pharm Pharm Scien.2014; 6(2):62-65.
- Sharma V, Nagpal M, Jain U K, Mangotia A and Kumar R. Anti diabetic drug and combination therapy ARPB,2013;3(2):389-394.
- Ali S H and Reddy B R. Formulation and evaluation of bilayer tablet of atorvastatin and pioglitazone form etabolic disorder. IAJPS. 2014; 1(6):448-455.
- Banu H, Mostafa R, Muhammad S, Irin D And Ashraful S; Formulation Development Of Bi-Layer Acetaminophen Tablets For Extended Drug Release; J. Chem. Pharm. Res;2011;3(6);348-360.
- Bhandari A, Bilayer tablet or a solid drug delivery system and challenges in the formulation: Anre view; IJPRD; 2011; vol. 4(03); may-2010 29-44.
- ChienY.W. Novel drug delivery systems; 2nd Ed.; Marcel DekkerInc: NewYork: 1992; 139-40.
- .Gudsoorkar V. R, Rambhau D.; Sustained release of drugs; The Eastern Pharmacist, 1993; 36(429); 17-22.
- Hoffman A.; Pharmacodynamic aspects of sustained release preparations; Adv Drug Del Rev; 1998; 33: 185-99.
- Hui H. W, Robinson J. R, Lee V. H. L.; Design and fabrication of oral controlled release drug delivery systems. In: Robinson JR, Lee V, editors. Controlled drug delivery fundamentals and applications; 2nd Ed.; Marcel Dekker: New York: Inc; 2005; 373-4.
- Jain N. K.; Controlled and novel drug delivery; 1stEd. CBS Publishers; New Delhi; 2002; 275-318.
- Pujara N; Bilayer tablet – Anemerg in gtrend; IJPRD; 2011; vol.4 (04); june-2012; 102-111.
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