Methyl Vanillate Ether Derivatives as Future Potential Drug

Authors

  • Maruti S. Satpute  Department of Chemistry, R. D. National College and W. A. Science College, Linking Road, Bandra (W), Mumbai, Maharashtra, India
  • Vijay D. Gangan  Department of Chemistry, Loba R & D Centre, Loba Chemie Pvt. Ltd., Plot No. D - 22, Tarapur, MIDC, Boisar, Palghar, Maharashtra, India
  • Indu Shastri  Department of Chemistry, R. D. National College and W. A. Science College, Linking Road, Bandra (W), Mumbai, Maharashtra, India

DOI:

https://doi.org//10.32628/IJSRST19616

Keywords:

Vanillic Acid, IR, 1HNMR, TOF MS, DCC, DMAP, Antibacterial, Ditch-Plate Method

Abstract

Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a dihydroxybenzoic acid derivative used as a flavouring agent. It is used in the synthesis of various active pharmaceutical ingredients such as Etamivan, Modecainide, Brovanexine, Vanitiolide, Vanyldisulfamide etc. In this paper, novel ether derivatives of vanillic acid were synthesized and tested for potential antibacterial activity. This combinatorial synthesis of novel vanillic acid ether derivatives can be a useful approach to generate potent chemotherapeutic agents in developing new drug candidates.

References

  1. L.. W. Wattenberg, J. B. Coccia and L. K.Lam,Cancer Res., 1980, 40, pp. 2820 - 2823.
  2. P. Talalay, M. J. De Long andH. J. Prochaska,Proc. Natl. Acad. Sci., 1988, 85, pp. 8261 - 8265.
  3. J. J. Macheix, A. Fleuriet andJ. Billot,Fruit phenolics. CRC press Inc., Boca Raton1990, FL.
  4. K. Natarajan, S. Singh, T. R. Burke Jr., D. Grunberger andB. B. Aggarwal, Proc. Natl. Acad. Sci.,1996, 93, pp. 9090 - 9095.
  5. C. Chiao, A. M. Carothers, D. Grunberger, G. Solomon, G. A. Preston and J. C. Barrett, Cancer Res., 1995, 55, pp. 3576 - 3583.
  6. T. R. Burke Jr, M. R. Fesen, A. Mazumder, J. Wang, A. M. Carothers, D. Grunberger, J. Driscoll, K. Kohn andY. Pommier, J. Med. Chem., 1995, 38(21), pp. 4171-4178.
  7. J. S. Bose, V. D. Gangan, S. K. Jain and S. K. Manna, J. Cell Physiol., 2009, 218(3), pp. 653 - 662.
  8. J. S. Bose, V. D. Gangan, S. K. Jain and S. K. Manna, Journal of Clinical Immunology,2009, 29, pp. 90 - 98.
  9. J. S. Bose and V. D. Gangan. (2007), Applied for US patent on “NOVEL CHEMOTHERAPEUTIC AGENTS AGAINST INFLAMMATION AND CANCER” from Reliance Life Sciences [INDIA 1696/MUM/2006, Publication No. WO/2008/062466, [International Application No. PCT/IN2007/000488].
  10. M. S. Satpute, I. Shastri and V. D. Gangan, Rasayan Journal of Chemistry, 2018 (In Press).
  11. M. S. Satpute, I. Shastri and V. D. Gangan, International Journal of Scientific Research in Science and Technology, 4 (11), November-December-2018, pp. 219-223.
  12. M. S. Satpute, I. Shastri and V. D. Gangan,International Journal for Research in Applied Science & Engineering Technology (IJRASET), 6 (XII), Dec 2018, pp. 330 - 334.
  13. M. S. Satpute, I. Shastri and V. D. Gangan, Communicated to Rasayan Journal of Chemistry, 2019.
  14. V. D. Gangan and S. S. Sankhe, International Journal of Scientific Research in Science and Technology, 4 (2), January-2018, pp. 886 - 891.
  15. M. G. R. Priya, K. Girija and N. Ravichandran, Rasayan journal of chemistry, 4 (2), 2011, pp. 418 - 424 and the references cited theirin.
  16. H. Pawar, N. Chaudhary, S. Singh, Rasayan journal of chemistry, Vol. 4 (3), 2011, pp. 498 - 505 and the references cited theirin.
  17. A. K. Babu and K. Selvaraju. Rasayan journal of chemistry, 11 (4), 2011, pp. 1501 - 1505 and the references cited theirin.
  18. T. M. Siregar, E. Budianto, H. Cahyana and W. Wibowo, Rasayan journal of chemistry, 11 (4), 2011, pp. 1765 - 1770 and the references cited theirin.
  19. P. M. G. Swamy and Y. S. Agasimundin, Rasayan journal of chemistry, 3 (2), 2008, pp. 421 - 428 and the references cited theirin.
  20. a) K. D. Mwambete and F. Lyombe, Indian J. Pharm. Sci., 2011, 73 (1), pp. 92 - 98. b ) T. Al lafiet. al., Dental Journal, 1995, 45 (3), pp. 218 - 222.

International Journal of Scientific Research in Science and Technology

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Published

2019-01-30

Issue

Volume 6, Issue 1, January-February-2019

Section

Research Articles

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How to Cite

[1]
Maruti S. Satpute, Vijay D. Gangan, Indu Shastri, " Methyl Vanillate Ether Derivatives as Future Potential Drug, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 6, Issue 1, pp.129-134, January-February-2019. Available at doi : https://doi.org/10.32628/IJSRST19616