Development and Evaluation of Floating Tablets of Pantoprazole

Authors

  • Sandhyarani Awatade  Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Tal. Sangola Dist. Solapur. Solapur University, Maharashtra, India
  • Ritesh Bathe  Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Tal. Sangola Dist. Solapur. Solapur University, Maharashtra, India
  • Swapna Mane  Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Tal. Sangola Dist. Solapur. Solapur University, Maharashtra, India

DOI:

https://doi.org//10.32628/IJSRST196167

Keywords:

Pantoprazole, Floating Drug Delivery, Citric Acid, Buoyancy, Direct Compress

Abstract

The present study was undertaken with an aim to design, develop and evaluate floating tablet of Pantoprazole, which release the drug in a sustained manner over a period of 12 hours. In this research work used hydroxy propyl methyl cellulose (HPMC K4M), gas generating agent sodium bicarbonate and citric acid. The high level of HPMC K4M and citric acid favors preparation of floating tablet Pantoprazole. The tablets were prepared by direct compression techniques and evaluated thickness, hardness, weight variation, friability, floating lag time and In-vitro drug release studies indicated that the floating dosage form showed slower release as concentration of HPMC K4M increases. Formulation F1 was considered as optimized formulation which shows satisfactory sustained drug release and remained buoyant on the surface of medium for more than 12 hrours. It can also conclude that floating drug delivery system of Pantoprazole can be successfully formulated as an approach to increase gastric residence time and thereby improving its bioavailability.

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International Journal of Scientific Research in Science and Technology

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Published

2019-02-28

Issue

Volume 6, Issue 1, January-February-2019

Section

Research Articles

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How to Cite

[1]
Sandhyarani Awatade, Ritesh Bathe, Swapna Mane, " Development and Evaluation of Floating Tablets of Pantoprazole, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 6, Issue 1, pp.452-467, January-February-2019. Available at doi : https://doi.org/10.32628/IJSRST196167