Simultaneous UV Spectrophotometric Estimation of Amlodipine and Chlorthalidone in Bulk and Combined Tablet Dosage Form

Authors(4) :-Sunil More, Ashpak Tamboli, Snehal Patil, Amol Vhanmane

There is not a single analytical methods appeared in the literature for combined estimation of Amlodipine and Chlorthalidone in tablets dosage form. Attempts were made to develop a simple, precise and accurate Simultaneous UV spectroscopic method of Amlodipine and Chlorthalidone in bulk and Amlodac CH tablet dosage form by using simultaneous equation method. UV spectrophotometric method was developed and validated as per ICH guidelines using methanol as mobile phase. Amlodipine and Chlorthalidone individually follows the Beer-Lamberts law over concentration range 2.5-12.5μg/ml and 6.25-31.5μg/ml, Regression of coefficient was found to be r2=0.999 and r2=0.999 respectively. The percentage recovery was found in the range of 98% to 102% at three different levels. The proposed method was successfully applied for the determination of Amlodipine and Chlorthalidone in tablets dosage form as per ICH guidelines the result of the analysis were validated statistically and were found to be satisfactory.

Authors and Affiliations

Sunil More
Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola, Solapur, Maharashtra, India
Ashpak Tamboli
Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola, Solapur, Maharashtra, India
Snehal Patil
Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola, Solapur, Maharashtra, India
Amol Vhanmane
Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola, Solapur, Maharashtra, India

Amlodipine (AML), Chlorthalidone (CLT), Simultaneous Equation, Validation, UV Spectrophotometer.

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Publication Details

Published in : Volume 6 | Issue 1 | January-February 2019
Date of Publication : 2019-02-28
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 468-472
Manuscript Number : IJSRST196168
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Sunil More, Ashpak Tamboli, Snehal Patil, Amol Vhanmane, " Simultaneous UV Spectrophotometric Estimation of Amlodipine and Chlorthalidone in Bulk and Combined Tablet Dosage Form ", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 6, Issue 1, pp.468-472, January-February-2019. Available at doi : https://doi.org/10.32628/IJSRST196168    
Journal URL : https://ijsrst.com/IJSRST196168
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