In Silico Analysis and Molecular Modelling of NS2B-NS3 Protein in Dengue

Abstract

Dengue fever is frequently born viral infection caused by female mosquito Aedes egypti. Transmission of dengue infection is transfer from one host to another by infected mosquito bite. Dengue virus is categorized into various serotypes on the basis of their genetic material variable. Dengue fever and dengue haemorrhagic fever is serious risk factor to Mankind Nowdays there is no specific vaccine to treat the dengue infection. There is need to design potent antiviral vaccine against dengue fever. NS2B-NS3 act as potent drug target in dengue fever. Hence our present work to achieve to understand detail molecular properties of NS2B-NS3 protein by retrieving its amino acid sequence from protein database like PDB. Analysis of physicochemical parameters, secondary and tertiary structure prediction. structure visualization is done by using Rasmol structure visualization tool. Predicted model is validated using procheck analysis. This all information gives primary information for future work to perform computer aided drug design against dengue fever.