Biological activates of 1,2,3-Triazole in Heterocyclic Compounds

Authors(2) :-Smit B Patel, V. G. Patel

1,3-Dipolar cycloaddition reactions can be considered a powerful synthetic tool in the building of heterocyclic rings, with applications in different fields. In this review we focus on the synthesis of biologically active compounds possessing the 1,2,3-triazole core through 1,3-dipolar cycloaddition reactions. The 1,2,3-triazole skeleton can be present as a single disubstituted ring, as a linker between two molecules, or embedded in a polyheterocycle. The cycloaddition reactions are usually catalysed by copper or ruthenium. Domino reactions can be achieved through dipolarophile anion formation, generally followed by cyclisation. The variety of attainable heterocyclic structures gives an illustration of the importance of the 1,2,3-triazole core in medicinal chemistry.

Authors and Affiliations

Smit B Patel
Department of Chemistry, Municipal Arts and Urban bank Science College, Mehsana, Hemchandaracharya North Gujarat University, Patan, Gujarat, India
V. G. Patel
Department of Chemistry, Municipal Arts and Urban bank Science College, Mehsana, Hemchandaracharya North Gujarat University, Patan, Gujarat, India

Nitrogen Heterocycles, Enzyme Catalysis, Biological Activity, Medicinal, Chemistry

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Publication Details

Published in : Volume 3 | Issue 8 | November-December 2017
Date of Publication : 2017-11-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 1950-1953
Manuscript Number : IJSRST196463
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Smit B Patel, V. G. Patel, " Biological activates of 1,2,3-Triazole in Heterocyclic Compounds", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 8, pp.1950-1953, November-December-2017.
Journal URL : http://ijsrst.com/IJSRST196463

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