Derivatives of Novel Pyrazolines and their Design, synthesis and Microbiological Activities

Authors

  • Smit B. Patel  Department of Chemistry, Municipal Arts and Urban bank Science College, Mehsana, Hemchandaracharya North Gujarat University, Patan, Gujarat, India
  • V. G. Patel  Department of Chemistry, Municipal Arts and Urban bank Science College, Mehsana, Hemchandaracharya North Gujarat University, Patan, Gujarat, India

Keywords:

AXITINIB, Method Development, Validation, 254nm, 3.0min.

Abstract

A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of AXITINIB. Isocratic elution at a flow rate of 1.2 ml /min was employed on a symmetry C18 column at ambient temperature. The mobile phase consisted of Acetonitrile : 0.1M Acetic Acid 50:50 (v/v). The UV detection wavelength was at 254 nm. Linearity was observed in concentration range of 10-50 ppm. The retention time for AXITINIB was 3.0 min. The method was validated as per the ICH guidelines. The proposed method can be successfully applied for the estimation of AXITINIB.

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International Journal of Scientific Research in Science and Technology

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Published

2019-07-30

Issue

Volume 6, Issue 4, July-August-2019

Section

Research Articles

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Copyright (c) IJSRST

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Smit B. Patel, V. G. Patel, " Derivatives of Novel Pyrazolines and their Design, synthesis and Microbiological Activities, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 6, Issue 4, pp.372-376, July-August-2019.