Effect of Contrast Media used in Coronary Angiography on Thyroid Function

Authors

  • Khaled S. El-Hadidy  Internal Medicine Department, Faculty of Medicine, Beni-Suef University, Egypt
  • Rania E. Sheir  Internal Medicine Department, Faculty of Medicine, Beni-Suef University, Egypt
  • M.N. Salem  Internal Medicine Department, Faculty of Medicine, Beni-Suef University, Egypt
  • Ahmed M. EL-Dien  Internal Medicine Department, Faculty of Medicine, Beni-Suef University, Egypt
  • Yasser A. Abd El-Hady  Cardiology Department, Faculty of Medicine, Beni-Suef University, Egypt

DOI:

https://doi.org//10.32628/IJSRST196468

Keywords:

Coronary Angiography, Iodinated Contrast Media, Thyroid function, Wolff-Chaikoff effect.

Abstract

Radiocontrast-induced thyroid dysfunction prevalence has not been assessed accurately. It is greater among patients with pre-existing thyroid disease. Aim of this work to investigate effect of iodinated radiographic contrast media used in coronary angiography on the thyroid function in euthyroid patients. This study was conducted on 85 patients underwent elective coronary angiography. Baseline assessment of Free Thyroxine (FT4) and Thyroid-stimulating hormone (TSH) for the patients and three months later after Coronary Angiography. We observed that there was a statistically significant increase of TSH levels from baseline till 3 months following administration of contrast media (P-value=0.007). However, there was no statistical significant difference of Free T4 level from baseline till 3 (P-value=0.765). The incidence of increased TSH above normal range was 2.4% after 3 months ( 2 subclinical hypothyroidism cases). We noticed that there were no effect of age, gender, hypertension, diabetes, type of contrast, creatinine level or GFR on increased the level of TSH above normal value after 3 months. So, administration of Iodinated Contrast Media (ICM) associated with thyroid dysfunction mainly subclinical hypothyroidism so we should closely monitor patients after receiving ICM especially who have thyroid dysfunction.

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International Journal of Scientific Research in Science and Technology

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Published

2019-08-31

Issue

Volume 6, Issue 4, July-August-2019

Section

Research Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Khaled S. El-Hadidy, Rania E. Sheir, M.N. Salem, Ahmed M. EL-Dien, Yasser A. Abd El-Hady, " Effect of Contrast Media used in Coronary Angiography on Thyroid Function, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 6, Issue 4, pp.339-344, July-August-2019. Available at doi : https://doi.org/10.32628/IJSRST196468