To Perform Development and Validation of HPLC Method for Analysis of Anticancer Drug Ifosfamide

Abstract

The oretical the as of now distributed Ifosfamide (IFF) explanatory strategies need to muddle techniques and gear, the goal of this paper was to introduce the approval of a straightforward, quick, exact and explicit isocratic UV and HPLC strategy for measurement of Ifosfamide. So this technique will be important during the future improvement of novel or inventive, intravenous medication details for treatment of bosom diseases. Approved technique exhibited Ifosfamide partition without obstracting from the solvents (that is Mensa) with the most significance for creating of intravenous pharmaceutical medication conveys (mensa and ordinary saline water). The UV Spectroscopy, Slope 0.055, Intercept 0.005 and Regression Coefficient 0.997 was found likewise to perform UV Spectroscopy technique approval parameter like linearity (relapse coefficient=0.994), exactness (intraday= % R.S.D.- 0.3203 and interda =% R.S.D-0.3240), precision (97.46-100.23%), LOD (0.3µg/ml) and LOQ (0.91 µg/ml) and toughness (investigator 1= % R.S.D.- 0.80 and examiner 2= % R.S.D- 1.70, power (0.086). Created UV technique is straightforward and monetary. Strategy was direct over considered Ifosfamide focus go (2-10 µg/mL) with passable exactness and precision. LOQ and LOQ 16.05µg/mL and 48.64µg/mL, individually. The Development and approval of Ifosfamide was effectively completed by utilizing UV and HPLC strategy.