Design, Synthesis and Biological Evaluation of Novel 1, 3, 4-Oxadiazole Bearing Pyridine Moiety

Authors(2) :-Asma D. Ambekari, Shrinivas K. Mohite

Series of novel substituted Synthesis of N-{[5-(substituted)-1,3,4-oxadiazole-2-yl] carbamothioyl} derivatives containing 1,3,4-oxadiazole moiety were synthesized by microwave as a green chemistry method and conventional method by using pyridine 3- carboxylic acid as a starting material. The structures of the synthesized compounds were characterized by physicochemical data, IR, Mass spectra and 1HNMR. All the newly synthesized compound screened for their antimicrobial and In-vivo and In-vitro Anti-inflammatory studies. Anti-inflammatory studies revealed that compound 4f showed significant in-vivo and in-vitro anti-inflammatory activity as well potent antimicrobial activity.

Authors and Affiliations

Asma D. Ambekari
Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India
Shrinivas K. Mohite
Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India

Pyridine 3- carboxylic acid, 1,3,4-oxadiazole, Anti-inflammatory activity.

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Publication Details

Published in : Volume 6 | Issue 5 | September-October 2019
Date of Publication : 2019-10-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 300-307
Manuscript Number : IJSRST196535
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Asma D. Ambekari, Shrinivas K. Mohite, " Design, Synthesis and Biological Evaluation of Novel 1, 3, 4-Oxadiazole Bearing Pyridine Moiety", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 6, Issue 5, pp.300-307, September-October-2019. Available at doi : https://doi.org/10.32628/IJSRST196535    
Journal URL : https://ijsrst.com/IJSRST196535
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