Review on Hot Melt Extrusion Technology and it's Application

Authors

  • Mali A. S.  Department of Pharmaceutics, Government College of Pharmacy Karad, Tal - Karad , Dist - Satara, Maharashtra, India
  • Gavali K. V.  Department of Pharmaceutics, Government College of Pharmacy Karad, Tal - Karad , Dist - Satara, Maharashtra, India
  • Choudhari R. G.  Department of Pharmaceutics, Government College of Pharmacy Karad, Tal - Karad , Dist - Satara, Maharashtra, India
  • Anekar V. P.  Department of Pharmaceutics, Government College of Pharmacy Karad, Tal - Karad , Dist - Satara, Maharashtra, India
  • Gavhane Y. N.  Department of Pharmaceutics, Government College of Pharmacy Karad, Tal - Karad , Dist - Satara, Maharashtra, India

DOI:

https://doi.org//10.32628/IJSRST196653

Keywords:

Hot-Melt Extrusion , Targeted Drug Delivery, Bioavailability.

Abstract

The use of hot-melt extrusion (HME) within the pharmaceutical industry is steadily increasing, due to proven its ability to efficiently manufacture novel products. With the use of HME we can increase solubility and bioavailability of the API. HME has proven to be a robust method of producing numerous drug delivery systems like modified, controlled and targeted drug delivery systems. resulting improved bioavailability as well as taste masking of bitter active pharmaceutical ingredients (APIs). Hot-melt extrusion techniques are pragmatic in the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, suppositories, implants, stents, transdermal systems and ophthalmic inserts. In This paper we review about the types of Extruder, solid dispersion and Application of the HME to the pharmaceutical industries.

References

  1. Repka, M., Majumdar S., Battu, S.K. et al..“Application of hot-melt extrusion for drug delivery,”Expert Opin. Drug.Deliv. 5 2012 p no. 1357–1376 (2008).
  2. Giulia L., Alessandra M., et al. “Evaluation of hot-melt extrusion technique in the preparation of HPC,”European Journal of Pharmaceutical Sciences.p no.77-85 (2014).
  3. M.Maniruzzaman, J. S. Boateng, M. Bonnefille, A. Aranyos, J. C. Mitchell, and D. Douroumis, “Taste masking of paracetamol by hot melt extrusion: an in vitro and in vivo evaluation,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 80, no. 2, p no. 433–442, (2012 ).
  4. M. A. Repka, S. Shah, J. Lu et al., “Melt extrusion: process to product,” Expert Opinion on Drug Delivery, vol. 9, no. 1, pp. 105–125, (2012).
  5. M. A. Repka, S.Majumdar, S. K. Battu, R. Srirangam, and S. B. Upadhye, “Applications of hot-melt extrusion for drug delivery,” Expert Opinion on Drug Delivery, vol. 5, no. 12, pp. 1357– 1376, (2008).
  6. M. A. Repka, S. K. Battu, S. B. Upadhye et al., “Pharmaceutical applications of hot-melt extrusion: part II,” Drug Development and Industrial Pharmacy, vol. 33, no. 10, pp. 1043–1057, (2007).
  7. Mohammed Maniruzzaman, Joshua S. Boateng, Martin J. Snowden,1 and Dennis Douroumis, “A Review of Hot-Melt Extrusion: Process,” Technology to Pharmaceutical Products International Scholarly Research Network page no 1 to 9 (2012).
  8. Sturges, J.D. Improvement in apparatus for cooling and mixing soap. US Patent 114063,(1877).
  9. RinaChokshi, Hossein Zia,“Hot-Melt Extrusion Technique: A Review,” Iranian Journal of Pharmaceutical Research 3 to 16(2004).
  10. Ankitpatel, Deepak Sahu, Ashok Dashora, “A Review of Hot Melt Extrusion Technique International Journal of Innovative Research in Science, Engineering and Technology,”Vol. 2, p no. 2194 to 2198 (2014).
  11. Pfleiderer, P., “Innovations on kneading and mixing machines of Freyburger type,” German Patent 18797, (1882).
  12. Kruder GA.,“Extrusion. In: Encyclopedia of Polymer Science and Engineering”Vol. 1, 2nd ed. John Wiley & Sons Inc., New York 571-631(1985).
  13. Breitenbach J.,“Melt extrusion: from process to drug delivery technology,”Eur. J. Pharm. Biopharm. p no.107-117 (2002).
  14. SandhyaPamu ,C. V. S. Subrahmanyam and K. S. K. RaoPatnaik Hot melt extrusion technique and its pharmaceutical applications: A review international journal of pharmacy and analytical research Vol.3 524 to 530 (2014).
  15. J.W.McGnity and J. J. KOleng, “Preparation and evaluation of rapid release granules using novel melt extrusion technique,” American Association of Pharmaceutical Scientists, p no. 153– 154, (2004).
  16. D. S. Jones, “Engineering drug delivery using polymer extrusion/ injection moulding technologies,” School of Pharmacy, vol. 4-9, pp. 18–27, (2008).
  17. H. H. Grunhagen and O. Muller, “Melt extrusion technology,” Pharmaceutical Manufacturing International, vol. 1, pp. 167– 170, (1995).
  18. S. Singhal, V. K. Lohar, and V. Arora, “Hot-melt extrusion technique,” WebmedCentral Pharmaceutical Sciences, vol. 2, no. 1, Article ID 001459, 2011.
  19. DevendraRidhurkar, Attila Vajdai1 and ZsoltZsigmond, “Hot-melt extrusion (HME)and its application for pharmacoki¬netic improvement of poorly water soluble drugs,”Journal in the field ofPharmacology, Toxicology andBiomedical Reports
  20. J. Breitenbach, “Melt extrusion: from process to drug delivery technology,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 54, no. 2, p no. 107–117, (2002).
  21. M.Mollan, “Historical overview in Pharmaceutical Extrusion Technology,” I. Ghebre-Sellassie and C. Martin, Eds., p no. 1–18, CRC Press, New York, NY, USA, (2003).
  22. A. Senouci, A. Smith, and P. Richmond, “Extrusion cooking,” Chemical Engineer, no. 417, p no. 30–33, (1985).
  23. E. Sebestyen, “Problems of grains preservation in storage facilities,” Journal of Flour and Animal FeedMilling, vol. 10, p no. 24– 25, (1974).
  24. D. J. Wedlock and D. V. Wijngaarden, “Fast dispersing solid PVP-containing crop protection formulation and process therefore,” US Patent 1992, 5: 665, 369.
  25. M.Maniruzzaman, M. Rana, J. S. Boateng, and D. Douroumis, “Dissolution enhancement of poorly water-soluble APIs processed by hot-melt extrusion using hydrophilic polymers,” Drug development and Industrial Pharmacy. p no 1254 to 1274 (2012)
  26. X. Zheng, R. Yang, X. Tang, and L. Zheng, “Part I: characterization of solid dispersions of nimodipine prepared by hotmelt extrusion,” Drug Development and Industrial Pharmacy, vol. 33, no. 7, p no. 791–802, (2007).
  27. Mollan M., Historical Overview in Pharmaceutical Extrusion Technology, edsGhebre-Sellasie, I. & Martin C. (Marcel Dekker, Inc., New York), p no 1-18,(2003).\
  28. Matthew W., Marcia w., David J. & Gavin A.,“Hot-melt extrusion technology and pharmaceutical application,” future science p no. 786 to 797 (2012).

International Journal of Scientific Research in Science and Technology

Downloads

Published

2019-12-30

Issue

Volume 6, Issue 6, November-December-2019

Section

Research Articles

License

Copyright (c) IJSRST

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Mali A. S., Gavali K. V., Choudhari R. G., Anekar V. P., Gavhane Y. N., " Review on Hot Melt Extrusion Technology and it's Application, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 6, Issue 6, pp.253-260, November-December-2019. Available at doi : https://doi.org/10.32628/IJSRST196653