A Review Extended Release Oral Drug Delivery System and Multiparticulate Drug Delivery Systems (MDDS)

Authors

  • Swapnil B. Khambat  R. C. Patel Institute of Pharmaceutical Education and Research.Shirpur, Dhule, Maharashtra, India
  • Shubham A. Kale.  R. C. Patel Institute of Pharmaceutical Education and Research.Shirpur, Dhule, Maharashtra, India

DOI:

https://doi.org//10.32628/IJSRST207124

Keywords:

Extended Release, Oral Route, Therapeutic Concentration, Pellet, Dosage Form

Abstract

The extended release product will optimize therapeutic effect and safety of a drug at the same time improving the patient convenience and compliance. By incorporating the dose for 24 hrs into one tablet/capsule from which the drug is released slowly. The concept of multiple unit dosage form was initially introduced in the early 1950’s.These forms play a major role in the design of solid dosage form processes because of their unique properties and the flexibility found in their manufacture. These forms can be defined as oral dosage forms consisting of a multiplicity of small discrete units, each exhibiting some desired characteristics. The release of drug from pellets depends on a variety of factors including the carrier used to form pellets and the amount of drug contained in them. Consequently, pellets provide tremendous opportunities for designing new controlled and extended release oral formulations, thus extending the frontier of future pharmaceutical development. The possible mechanism for drug release includes solution/diffusion through the continuous polymer phase or plasticizer channels, diffusion through aqueous pores and osmotically driven release through aqueous pores. To distinguish between these mechanisms, the release rate was studied as a function of coating thickness, plasticizer content and osmotic pressure in the dissolution medium.

References

  1. Pfizer, Detrol® L.A. tolterodine tartrate extended release capsule, http://www.drugbank.ca/system/fda_labels/ DB01036.pdf). Accessed October 2011.
  2. Ehab Ahmed MH. Ph.D. Thesis: Application and evaluation of extended release technology to loop diuretics. University of Cincinnati (2002): 78-82.
  3. Madhusudhan P and Nazeer S: Extended release formulation. International Journal of Pharmacy and Technology 2010; 2: 625- 684.
  4. Hayashi T. Formulation, study and drug release mechanism of a new Theophylline sustained release preparation, Int. J Pharm., 2005; 304: 91-101.
  5. Shaji J, Chadawar V and Talwalkar P:Multiparticulate Drug Delivery System. The Indian Pharmacist. 2007;6(60):21-28.
  6. Dashora K, Saraf S and Saraf S. Development of sustained release multicomponent microparticulate system of Diclofenac sodium and Tizanidine hydrochloride. Int J Pharm Sci and nanotechnology. 2008;1:98-105.
  7. Jamila Hamdani, Andre´ J. Moe¨s and Karim Amighi, 2002. Development and evaluation of prolonged release pellets obtained by the melt pelletization process. International Journal of Pharmaceutics, 245, 167-177.
  8. Vinayak D Kadam and Surendra G Gattani, 2009. Effect of Curing Time on pH and Time Dependant Coated Pellets. International Journal of Health Research, 2(1), 75-81.
  9. F. Podczeck, P.E. Knight and J.M. Newton, 2008. The evaluation of modified microcrystalline cellulose for the preparation of pellets with high drug loading by extrusion/spheronization. International Journal of Pharmaceutics, 350, 145–154.
  10. Srujan Reddy, Palash Das, Harika Das and Arpita Ghosh, 2011. MUPS (Multiple Unit Pellet System) Tablets - A Brief Review. Journal of Pharmaceutical and Biomedical Sci., 12(02), 1-5.
  11. Thoma K and Ziegler I: The pH independent release of fenoldopam from pellets with insoluble film coats. Eur J Pharm and Biopharm. 1998;46(1):105-113.
  12. Nikolett Kállai, Oliver Luhn, Judit Dredán, Kristóf Kovács, Miléna Lengyel and István Antal, 2010. Evaluation of drug release from coated pellets based on isomalt, sugar and microcrystalline cellulose inert cores. AAPS Pharm. Sci.Tech., 1(1), 383-391.
  13. Guanhao Ye, Siling Wang, Paul Wan Sia Heng, Ling Chen and Chao Wang, 2007. Development and optimization of solid dispersion containing pellets of Itraconazole prepared by high shear pelletization. International Journal of Pharmaceutics, 337, 80–87.
  14. C.P. Jain and P.S. Naruka, 2009. Formulation and evaluation of fast dissolving tablets of Valsartan. International Journal of Pharmacy and Pharmaceutical Sciences. 1(1), 219- 226.
  15. Dhirendra Kumar, Vivek Dave, Shaila Lewis, Brajesh Parmar, Kavita R. Gajbhiye, Sarvesh Paliwal, 2010. Design and evaluation of sustained-release matrix once daily formulation of Stavudine. International Journal of Drug Delivery, 2, 125-134.
  16. Gihan Nabil Fetih, 2010. Formulation and characterization of Gelucire pellets for sustain release of Ibuprofen. Bull. Pharm. Sci., Assiut University, 33(2), 217-224.
  17. Golam Kibria, KM Ariful Islam and Reza-Ul Jalil, 2009. Stability studies of Ambroxol Hydrochloride sustain release pellets coated with acrylic polymer. Pak. J. Pharm. Sci., 22(1), 36-43.
  18. V. S. N. Murthy Dwibhashyam and J. Vijayaratana, 2008. Key formulation variables in tableting of coated pellets. Indian Journal of Pharmaceutical Sciences, 70 (5), 555-564.
  19. Jaber Emami, Mona Tajeddin and Fatemeh Ahmadi, 2008. Preparation and In vitro evaluation of sustained-release matrix tablets of Flutamide using synthetic and naturally occurring polymers. Iranian Journal of Pharmaceutical Research, 7 (4), 247-257.
  20. Phutane P, Shidhaye S, Lotlikar V, Ghule A, Sutar S and Kadam V, 2010. In vitro evaluation of novel sustained release microspheres of Glipizide prepared by the emulsion solvent diffusion-evaporation method. J Young Pharmacists, 2, 35-41.
  21. Subal Chandra Basak, Kesevan Senthil Kumar and Murugesan Ramalingam, 2008. Design and release characteristics of sustained release tablet containing Metformin HCl. Brazilian Journal of Pharmaceutical Sciences, 44(3), 477-483.

International Journal of Scientific Research in Science and Technology

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Published

2020-02-10

Issue

Volume 7, Issue 1, January-February-2020

Section

Research Articles

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How to Cite

[1]
Swapnil B. Khambat, Shubham A. Kale., " A Review Extended Release Oral Drug Delivery System and Multiparticulate Drug Delivery Systems (MDDS), International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 7, Issue 1, pp.84-92, January-February-2020. Available at doi : https://doi.org/10.32628/IJSRST207124