Synthesis, Characterization and Evaluation of In Vivo Anti-Inflammatory Activity of N-Substituted-1,3,4-Oxadiazole Derivatives

Authors

  • Manisha Dhondising Rajput  Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, India
  • C. S. Magdum.  Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, India
  • S. K. Mohite  Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, India
  • S. R. Kane  Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, India

DOI:

https://doi.org//10.32628/IJSRST207155

Keywords:

Anti-Inflammatory, Oxadiazole, Aroyl Hydrazide

Abstract

The new series oxadiazole derivatives were prepared by reacting aromatic carboxylic acids.In the present work 10 different 5-substituted-1,3,4-oxadiazole -2-amine derivatives (3a -i) were synthesized. Substituted carboxylic acid is converted into substituted ethyl benzoate by esterification. Different ethyl benzoate is converted into different aroyl hydrazide by treating with hydrazine hydrate.The different aroyl hydrazide is converted 5-substituted-1,3,4-oxadiazole-2-amine derivatives by treating with cyanogen bromide.Confirmation of the chemical structure of the synthesized compounds was substantiated by TLC,IR,1H NMR, and MS spectroscopy.In present study,a series of 1,3,4-oxadiazole derivatives(3a- i)were evaluated for in vivo anti-inflammatory activity by carrageenan induced paw edema method. The results of anti-inflammatory evaluation revealed that compounds 3c, 3e and3i exhibited significant anti-inflammatory activity at a dose of 25 mg kg-1 compared to indomethacin used as the reference standard.The anti-inflammatory activity investigation highlights that the synthesized compound 3e could be considered for further clinical studies.

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International Journal of Scientific Research in Science and Technology

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Published

2020-02-29

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Volume 7, Issue 1, January-February-2020

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Research Articles

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[1]
Manisha Dhondising Rajput, C. S. Magdum., S. K. Mohite, S. R. Kane, " Synthesis, Characterization and Evaluation of In Vivo Anti-Inflammatory Activity of N-Substituted-1,3,4-Oxadiazole Derivatives, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 7, Issue 1, pp.234-239, January-February-2020. Available at doi : https://doi.org/10.32628/IJSRST207155