A Review - Carisoprodol as Skeletal Muscle Relaxant

Authors

  • A. A Patil  Nootan College of Pharmacy Kavathe-Mahankal, Ta-Kavathe, Mahankal, Sangli, Maharastra, India
  • M. K. Shirsat  Nootan College of Pharmacy Kavathe-Mahankal, Ta-Kavathe, Mahankal, Sangli, Maharastra, India
  • V. R. Salunkhe  Nootan College of Pharmacy Kavathe-Mahankal, Ta-Kavathe, Mahankal, Sangli, Maharastra, India

DOI:

https://doi.org//10.32628/IJSRST20716

Keywords:

Carisoprodol, Diazotization, Derivatization, Spectroscopy.

Abstract

In the world of pharmacology, the prescription of a medicine and its dosage play important role. Different physico-chemical methods are in vogue in describing the interactions of the drug molecule with host target among them, the chief being spectroscopic, chromatographic and quantum mechanical techniques. Skeletal muscle relaxants are divided into two categories: antispastic (for conditions such as cerebral palsy and multiple sclerosis) and antispasmodic agents (for musculoskeletal conditions). Antispastic agents (e.g., baclofen [Lioresal], dantrolene [Dantrium]) should not be prescribed for musculoskeletal conditions because there is sparse evidence to support their use. Rather, anantispasmodic agent may be more appropriate Many of the studies evaluating the effectiveness of skeletal muscle relaxants are hampered by poor methodologic design, including incomplete reporting of compliance, improper or no mention of allocation concealment, not utilizing intention-to-treat methods, and inadequate randomization. skeletal muscle relaxants have been evaluated in systematic reviews and meta-analyses.These include Methocarbamol, Meprobamate, Metaxalone, Carisoprodol, Dantrium and Baclofen. Chemically Carisoprodol is N-isopropyl-2-methyl-2-propyl-1,3-propanediol dicarbamate. Methods like nitration, Sulphonation, Methylation, Esterification, Acetylation and Diazotization was used for formation of new derivative which can be detected in UV region. Different reactions of diazotization were used for getting a new and novel derivative of Carisoprodol. Physiochemical properties, TLC, UV, IR and NMR analysis of Carisoprodol and newly obtained derivatives of Carisoprodol was studied and it showed that there was change in color, odour, taste, melting point, solubility pattern of original drug and derivatives.

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International Journal of Scientific Research in Science and Technology

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Published

2020-01-30

Issue

Volume 7, Issue 1, January-February-2020

Section

Research Articles

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How to Cite

[1]
A. A Patil, M. K. Shirsat, V. R. Salunkhe, " A Review - Carisoprodol as Skeletal Muscle Relaxant, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 7, Issue 1, pp.40-44, January-February-2020. Available at doi : https://doi.org/10.32628/IJSRST20716