Reviewing Therapeutic and Immuno-Pathological Applications of Vitamins and Carotenoids

Authors

  • Bharat Kwatra  Invenzion labs Inc. , India
  • Md Sadique Hussain  Lovely Professional University, Phagwara, Punjab, India
  • Ratul Bhowmik  Jamia Hamdard, New Delhi, India
  • Shalini Manoharan   Anna University, Chennai, Tamil Nadu, India

DOI:

https://doi.org//10.32628/IJSRST207473

Keywords:

Bioactive, Endothelial Cell, Vitamin D

Abstract

The present review is based mainly on papers published between 2000 and 2020 and gives information about the properties of the Vitamins and Carotenoids in chemical and biological systems and its possible role in preventing several diseases. The main aim of this report is to highlight its role as an immunopathological applications, also reported are bioactive properties that may influence the development of foam cells and protection against endothelial cell damage.

References

  1. Cooper, J. D. et al. Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes 60, (2011).
  2. Wang, J. et al. Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Nutrients vol. 7 (2015).
  3. Wessels, I. & Rink, L. Micronutrients in autoimmune diseases: possible therapeutic benefits of zinc and vitamin D. Journal of Nutritional Biochemistry vol. 77 (2020).
  4. Hayes, C. E. et al. Vitamin D actions on CD4+ T cells in autoimmune disease. Frontiers in Immunology vol. 6 (2015).
  5. Smyk, D. S., Orfanidou, T., Invernizzi, P., Bogdanos, D. P. & Lenzi, M. Vitamin D in autoimmune liver disease. Clinics and Research in Hepatology and Gastroenterology vol. 37 (2013).
  6. Van Belle, T. L., Gysemans, C. & Mathieu, C. Vitamin D in autoimmune, infectious and allergic diseases: A vital player? Best Practice and Research: Clinical Endocrinology and Metabolism vol. 25 (2011).
  7. Agmon-Levin, N., Theodor, E., Segal, R. M. & Shoenfeld, Y. Vitamin D in systemic and organ-specific autoimmune diseases. Clin. Rev. Allergy Immunol. 45, (2013).
  8. Baeke, F., Gysemans, C., Korf, H. & Mathieu, C. Vitamin D insufficiency: Implications for the immune system. Pediatric Nephrology vol. 25 (2010).
  9. Harrison, S. R., Li, D., Jeffery, L. E., Raza, K. & Hewison, M. Vitamin D, Autoimmune Disease and Rheumatoid Arthritis. Calcified Tissue International vol. 106 (2020).
  10. Cantorna, M. T., Zhao, J. & Yang, L. Vitamin D, invariant natural killer T-cells and experimental autoimmune disease. in Proceedings of the Nutrition Society vol. 71 (2012).
  11. Demirkaya, S. et al. Malondialdehyde, glutathione peroxidase and superoxide dismutase in peripheral blood erythrocytes of patients with acute cerebral ischemia. Eur. J. Neurol. (2001) doi:10.1046/j.1468-1331.2001.00166.x.
  12. Gariballa, S. E. & Sinclair, A. J. Assessment and treatment of nutritional status in stroke patients. Postgraduate Medical Journal (1998) doi:10.1136/pgmj.74.873.395.
  13. Hussein, G. et al. Antihypertensive and neuroprotective effects of astaxanthin in experimental animals. Biol. Pharm. Bull. (2005) doi:10.1248/bpb.28.47.
  14. Palozza, P. & Krinsky, N. I. Astaxanthin and canthaxanthin are potent antioxidants in a membrane model. Arch. Biochem. Biophys. (1992) doi:10.1016/0003-9861(92)90675-M.
  15. Shen, H. et al. Astaxanthin reduces ischemic brain injury in adult rats. FASEB J. (2009) doi:10.1096/fj.08-123281.
  16. Barber, P. A., Demchuk, A. M., Hirt, L. & Buchan, A. M. Biochemistry of ischemic stroke. Advances in neurology (2003) doi:10.1002/chin.200331291.
  17. Comhaire, F. H., El Garem, Y., Mahmoud, A., Eertmans, F. & Schoonjans, F. Combined conventional/antioxidant ‘Astaxanthin’ treatment for male infertility: A double blind, randomized trial. Asian J. Androl. (2005) doi:10.1111/j.1745-7262.2005.00047.x.
  18. Marchetti, C., Obert, G., Deffosez, A., Formstecher, P. & Marchetti, P. Study of mitochondrial membrane potential, reactive oxygen species, DNA fragmentation and cell viability by flow cytometry in human sperm. Hum. Reprod. (2002) doi:10.1093/humrep/17.5.1257.
  19. Virro, M. R., Larson-Cook, K. L. & Evenson, D. P. Sperm chromatin structure assay (SCSA®) parameters are related to fertilization, blastocyst development, and ongoing pregnancy in in vitro fertilization and intracytoplasmic sperm injection cycles. Fertil. Steril. (2004) doi:10.1016/j.fertnstert.2003.09.063.
  20. Chemes, H. E. & Rawe, V. Y. Sperm pathology: A step beyond descriptive morphology. Origin, characterization and fertility potential of abnormal sperm phenotypes in infertile men. Human Reproduction Update (2003) doi:10.1093/humupd/dmg034.
  21. Franco, J. G. et al. Significance of large nuclear vacuoles in human spermatozoa: Implications for ICSI. Reprod. Biomed. Online (2008) doi:10.1016/S1472-6483(10)60291-X.
  22. Higuera-Ciapara, I., Félix-Valenzuela, L. & Goycoolea, F. M. Astaxanthin: A review of its chemistry and applications. Critical Reviews in Food Science and Nutrition (2006) doi:10.1080/10408690590957188.
  23. Agarwal, A., Nallella, K. P., Allamaneni, S. S. R. & Said, T. M. Role of antioxidants in treatment of male infertility: An overview of the literature. Reproductive BioMedicine Online (2004) doi:10.1016/S1472-6483(10)61641-0.
  24. Yuan, J. P., Peng, J., Yin, K. & Wang, J. H. Potential health-promoting effects of astaxanthin: A high-value carotenoid mostly from microalgae. Molecular Nutrition and Food Research (2011) doi:10.1002/mnfr.201000414.
  25. Imamovic Kumalic, S. & Pinter, B. Review of clinical trials on effects of oral antioxidants on basic semen and other parameters in idiopathic Oligoasthenoteratozoospermia. Biomed Res. Int. (2014) doi:10.1155/2014/426951.
  26. NCT03460860. Nno: no outcome of interest Astaxanthin (2 mg) + Lycopene (1.8 mg) + D-Alpha-Tocopherol (10 IU) For The Treatment Of Skin Aging. https://clinicaltrials.gov/show/NCT03460860 (2018).
  27. NCT02373111. Effects of Isoflavone Combined With Astaxanthin on Skin Aging. https://clinicaltrials.gov/show/NCT02373111 (2015).
  28. NCT03368872. Clinical Trial of Astaxanthin Formulation With Exercise in Sarcopenia Elderly. https://clinicaltrials.gov/show/NCT03368872 (2017).
  29. NCT02343497. Lipid-lowering Effects of an Astaxanthin Supplement in Volunteers With Mild Dyslipidaemia. https://clinicaltrials.gov/show/NCT02343497 (2015).
  30. NCT02397811. Astaxanthin Formulation Bioavailability. https://clinicaltrials.gov/show/NCT02397811 (2015).
  31. Li, J. et al. Protective effects of astaxanthin on conainduced autoimmune hepatitis by the JNK/p-JNK pathway-mediated inhibition of autophagy and apoptosis. PLoS One (2015) doi:10.1371/journal.pone.0120440.
  32. Li, J. et al. Astaxanthin pretreatment attenuates hepatic ischemia reperfusion-induced apoptosis and autophagy via the ROS/MAPK pathway in mice. Mar. Drugs (2015) doi:10.3390/md13063368.
  33. Landon, R. et al. Impact of Astaxanthin on Diabetes Pathogenesis and Chronic Complications. Marine Drugs (2020) doi:10.3390/md18070357.
  34. Sakai, S. et al. Astaxanthin, a xanthophyll carotenoid, prevents development of dextran sulphate sodiuminduced murine colitis. J. Clin. Biochem. Nutr. (2019) doi:10.3164/jcbn.1847.
  35. Sakai, S. et al. Astaxanthin, a xanthophyll carotenoid, prevents development of dextran sulphate sodium-induced murine colitis. J. Clin. Biochem. Nutr. (2019) doi:10.3164/jcbn.18-47.
  36. Lotfi, A., Soleimani, M. & Ghasemi, N. Astaxanthin reduces demyelination and oligodendrocytes death in a rat model of multiple sclerosis. Cell J. (2021) doi:10.22074/cellj.2021.6999.
  37. Kimble, L., Mathison, B. & Chew, B. Astaxanthin Mediates Inflammation Biomarkers Associated with Arthritis in Human Chondrosarcoma Cells Induced with Interleukin-1β. Am. J. Adv. Food Sci. Technol. (2013) doi:10.7726/ajafst.2013.1004.
  38. Lindsey, K., Bridget, M. & Boon, C. Astaxanthin Mediates Inflammation Biomarkers Associated with Arthritis in Human Chondrosarcoma Cells Induced with Interleukin-1β. Am. J. Adv. Food Sci. Technol. (2013) doi:10.7726/ajafst.2013.1005.
  39. Miyachi, M., Matsuno, T., Asano, K. & Mataga, I. Anti-inflammatory effects of astaxanthin in the human gingival keratinocyte line NDUSD-1. J. Clin. Biochem. Nutr. (2015) doi:10.3164/jcbn.14-109.
  40. Juhlin, L. & Olsson, M. J. Improvement of vitiligo after oral treatment with vitamin B12 and folic acid and the importance of sun exposure. Acta Derm. Venereol. 77, (1997).
  41. Rubí, B. Pyridoxal 5’-phosphate (PLP) deficiency might contribute to the onset of type I diabetes. Med. Hypotheses 78, (2012).
  42. KASTRUP, W., MOBACKEN, H., STOCKBRÜGGER, R., SWOLIN, B. & WESTIN, J. Malabsorption of Vitamin B12 in Dermatitis Herpetiformis and Its Association with Pernicious Anaemia. Acta Med. Scand. 220, (1986).
  43. Kalarn, S. P. & Watson, R. R. Effects of B Vitamins in Patients with Multiple Sclerosis. in Nutrition and Lifestyle in Neurological Autoimmune Diseases: Multiple Sclerosis (2017). doi:10.1016/B978-0-12-805298-3.00026-8.
  44. Huang, S. C., Wei, J. C. C., Wu, D. J. & Huang, Y. C. Vitamin B6 supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis. Eur. J. Clin. Nutr. 64, (2010).
  45. Tourbah, A. et al. MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study. Mult. Scler. 22, (2016).
  46. Costantini, A. & Pala, M. I. Thiamine and fatigue in inflammatory bowel diseases: An open-label pilot study. J. Altern. Complement. Med. 19, (2013).
  47. Chan, C. Q. H., Low, L. L. & Lee, K. H. Oral Vitamin B12 replacement for the treatment of Pernicious Anemia. Frontiers in Medicine vol. 3 (2016).
  48. Naghashpour, M., Jafarirad, S., Amani, R., Sarkaki, A. & Saedisomeolia, A. Update on riboflavin and multiple sclerosis: A systematic review. Iranian Journal of Basic Medical Sciences vol. 20 (2017).
  49. Miller, A., Korem, M., Almog, R. & Galboiz, Y. Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. in Journal of the Neurological Sciences vol. 233 (2005).
  50. Costantini, A., Nappo, A., Pala, M. I. & Zappone, A. High dose thiamine improves fatigue in multiple sclerosis. BMJ Case Rep. (2013) doi:10.1136/bcr-2013-009144.
  51. Kwatra, B. A REVIEW ON POTENTIAL PROPERTIES AND THERAPEUTIC APPLICATIONS OF GRAPE SEED EXTRACT. World J. Pharm. Res. 9, 2519–2540 (2020).
  52. Kwatra, B. A REVIEW ON POTENTIAL PROPERTIES AND THERAPEUTIC APPLICATIONS OF BRANCHED CHAIN AMINO. WORLD J. Pharm. Pharm. Sci. 9, 561–588 (2020).
  53. Kwatra, B. & Arora, C. The Studying Of Movements Resonant the Pendulum Elastic. Indian J. Appl. Res. 10, 1–2 (2020).
  54. Kwatra, B. COLLAGEN SUPPLEMENTATION?: THERAPY FOR SKIN DISORDERS?: A REVIEW. World J. Pharm. Res. 9, 2504–2518 (2020).
  55. Kwatra, B. A REVIEW ON POTENTIAL PROPERTIES AND THERAPEUTIC APPLICATIONS OF LYCOPENE. Int. J. Med. Biomed. Stud. 4, 33–44 (2020).
  56. Kwatra, B. & Mudgil, M. LIGHT ASSISTED TIO2-BASED NANOCOMPOSITE SYSTEMS: A NOVEL TREATMENT FOR CANCER. Int. J. Med. Biomed. Stud. 4, 28–32 (2020).
  57. Kwatra, B. A Review on Potential Properties and Therapeutic Applications of Vitamin D. Int. J. Sci. Res. 9, 682–691 (2020).
  58. Kwatra, B. HYDROQUINONE: A novel growth inhibitor and apoptosis inducer in U-251 MG CELLS. Int. J. Med. Biomed. Stud. 3, 15–16 (2019).
  59. Kwatra, B. HACKING THE BLOOD-BRAIN BARRIER. Eur. J. Biol. Med. Sci. Res. 5, 10–13 (2017).
  60. Kwatra, B. EXPRESSION AND CHARACTERIZATION IN PICHIA PASTORIS BY CLONING OF DELTA 4 DESATURASE FROM ISOCHRYSIS GALBANA. Indian J. Appl. Res. 9, 1–2 (2019).
  61. Kwatra, B. CALCIUM AND IRON ABSORPTION: INVITRO STUDIES. Int. J. Med. Biomed. Stud. 3, 59–61 (2019).
  62. Kwatra, B. Allicin-An After Digestion Antimicrobial Agent. ACTA Sci. Microbiol. 2, 48–51 (2019).
  63. Kwatra, B. LOCATOR THEORY FOR ELE-MENTS IN PERIODIC TABLE ‘LEPT’. Glob. J. Pure Appl. Chem. Res. 5, 9–10 (2017).
  64. Kwatra, B. & Agarwal, R. Misfolded Proteins in Parkinson ’ s and Alzheimer Disease?: A Review Misfolded Proteins in Parkinson ’ s and Alzheimer Disease?: A Review. Int. J. Sci. Res. Sci. Technol. 7, 57–74 (2020).
  65. Kwatra, B. & A, A. UTERINE CANCER: SEX DOMINANT CHARACTER. Int. J. Adv. Res. 08, 663–667 (2020).
  66. Kwatra, B. Studies on People Employed in High Risk Workplace?: Between Genetic Polymorphism for Tumor Necrosis Factor ( TNF- Α ) and Blood Pressure. Int. J. Innov. Res. Technol. 6, 268–270 (2020).
  67. Kwatra, B. & Arora, C. Investigation of Conductance Quantization with Magnetic Field Control and Application of Biosensor. Int. J. Innov. Res. Technol. 6, 271–272 (2020).
  68. Kwatra, B. Candidate genes of OCD interacts with human retrovirus to form new link in inflammatory hypothesis. Int. J. Sci. Appl. Res. 7, 1–2 (2020).
  69. Kwatra, B. COLLAGEN SUPPLEMENTATION?: THERAPY FOR THE PREVENTION AND TREATMENT OF OSTEOPOROSIS AND OSTEOARTHRITIS?: A REVIEW. WORLD J. Pharm. Pharm. Sci. 9, 589–604 (2020).
  70. Kwatra, B. & Arora, C. THE UNEXPLAINED SIMILARITY BETWEEN THE ATOMIC AND GRAVITATIONAL MODELS. Int. J. Adv. Res. 8, 1099–1107 (2020).
  71. Kwatra, B. A Review on Potential Properties and Therapeutic Applications of DHA and EPA. ijppr.humanjournals 16, 140–176 (2019).
  72. Kwatra, B. Tinospora Crispa As A Future Cure For Obesity/Cholesterol. Int. J. Sci. Technol. Res. 6, 340–341 (2017).
  73. Bharat Kwatra. Procuring Natural Dye for Solar Cell Using Leaf Waste. Int. J. Sci. Eng. Res. 7, 46–47 (2019).
  74. Kwatra, B. THE SIMVASTATIN AND DMXAA ON THE CO-CULTURE OF B16.F10 MELANOMA CELLS AND MACROPHAGES SHOWS ANTITUMOR ACTIVITY. World J. Pharm. Res. 8, 1318–1319 (2019).
  75. Kwatra, B. Bioactive-Compounds: alternative to control Candida spp. Int. J. Sci. Res. Rev. 8, 221–223 (2019).
  76. Kwatra, B. Effects of Mineral Separation by Time and Enteric Coating Mechanism for Calcium and Iron Absorption in Mammalia. Int. J. Sci. Res. 8, 1265–1270 (2019).
  77. Kwatra, B. Maprovit 3, 6, 9: Perfect Companion of your Immune System to Fight Corona Virus Hit. Int. J. Sci. Res. 9, 241–241 (2020).
  78. Kwatra, B. & Mudgil, M. Untangling the Mathematical Relation Between Natural Selection and Adaptive Radiation Using Macromolecules and Microevolutionary Forces. Int. J. Sci. Res. Sci. Technol. IJSRST | 7, 313–339 (2020).
  79. Chaitanya Arora1, B. K. Mathematical and Statistical Approach to Define Past Present Future Events. Int. J. Sci. Res. 8, 261–263 (2019).
  80. Kwatra, B. MECHANISMS OF PATTERN FORMATION OF FBP17 IN MAST CELLS. Int. J. Adv. Res. 7, 413–414 (2019).
  81. Mudgil1, M. & Kwatra2, B. Mosquito Menace Aim: Observing the life cycle of Aedes aegypti mosquito and understanding its behavior towards different natural oils for encouraging natural methods of repellence. Int. J. Sci. Res. 8, 1314–1315 (2019).
  82. Kwatra, B. A REVIEW ON POTENTIAL PROPERTIES AND THERAPEUTIC APPLICATIONS OF BROMELAIN. www.wjpps.com 8, 488–500 (2019).
  83. Kwatra, B. Holothuroidea (Sea Cucumber): Key to Anti-Aging. Int. J. Sci. Res. 8, 884–884 (2019).
  84. Kwatra, B. & Mudgil, M. PROTONATED CRAB SHELL WASTE AS FUNGAL INHIBITOR. Int. J. Med. Biomed. Stud. 3, 111–116 (2019).
  85. Magbanua, M. J. M. et al. Physical activity and prostate gene expression in men with low-risk prostate cancer. Cancer Causes Control (2014) doi:10.1007/s10552-014-0354-x.
  86. Magbanua, M. J. M. et al. Gene expression and biological pathways in tissue of men with prostate cancer in a randomized clinical trial of lycopene and fish oil supplementation. PLoS One (2011) doi:10.1371/journal.pone.0024004.
  87. Moran, N. E. et al. Compartmental and noncompartmental modeling of 13C-lycopene absorption, isomerization, and distribution kinetics in healthy adults. Am. J. Clin. Nutr. (2015) doi:10.3945/ajcn.114.103143.
  88. Moran, N. E. et al. Absorption and distribution kinetics of the 13c-labeled tomato carotenoid phytoene in healthy adults. J. Nutr. (2016) doi:10.3945/jn.115.220525.
  89. Bostwick, D. G. et al. Independent origin of multiple foci of prostatic intraepithelial neoplasia: Comparison with matched foci of prostate carcinoma. Cancer (1998) doi:10.1002/(SICI)1097-0142(19981101)83:9<1995::AID-CNCR16>3.0.CO;2-2.
  90. Giovannucci, E. et al. Intake of carotenoids and retino in relation to risk of prostate cancer. J. Natl. Cancer Inst. (1995) doi:10.1093/jnci/87.23.1767.
  91. Jain, M. G., Hislop, G. T., Howe, G. R. & Ghadirian, P. Plant foods, antioxidants, and prostate cancer risk: Findings from case, control studies in Canada. Nutr. Cancer (1999) doi:10.1207/S15327914NC3402_8.
  92. Giovannucci, E. Tomatoes, tomato-based products, lycopene, and cancer: Review of the epidemiologic literature. Journal of the National Cancer Institute (1999) doi:10.1093/jnci/91.4.317.
  93. Pastori, M., Pfander, H., Boscoboinik, D. & Azzi, A. Lycopene in association with α-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells. Biochem. Biophys. Res. Commun. (1998) doi:10.1006/bbrc.1998.9351.
  94. Clinton, S. K. et al. cis-trans lycopene isomers, carotenoids, and retinol in the human prostate. Cancer Epidemiol. Biomarkers Prev. (1996).
  95. NCT00402285. Lycopene or Omega-3 Fatty Acid Nutritional Supplements in Treating Patients With Stage I or Stage II Prostate Cancer. https://clinicaltrials.gov/show/NCT00402285 (2006).
  96. NCT00450749. Lycopene in Treating Patients Undergoing Radical Prostatectomy for Prostate Cancer. https://clinicaltrials.gov/show/NCT00450749 (2007).
  97. Han, G. M. & Han, X. F. Serum lycopene is inversely associated with long-term all-cause mortality in individuals with rheumatoid arthritis: Result from the NHANES III. Eur. J. Integr. Med. (2016) doi:10.1016/j.eujim.2015.10.003.
  98. Aydin, M. & Çelik, S. Effects of lycopene on plasma glucose, insulin levels, oxidative stress, and body weights of streptozotocin-induced diabetic rats. Turkish J. Med. Sci. (2012) doi:10.3906/sag-1202-44.
  99. Kumar, A., Bagewadi, A., Keluskar, V. & Singh, M. Efficacy of lycopene in the management of oral submucous fibrosis. Oral Surgery, Oral Med. Oral Pathol. Oral Radiol. Endodontology (2007) doi:10.1016/j.tripleo.2006.07.011.
  100. Giri, A. K., Rawat, J. K., Singh, M., Gautam, S. & Kaithwas, G. Effect of lycopene against gastroesophageal reflux disease in experimental animals. BMC Complement. Altern. Med. (2015) doi:10.1186/s12906-015-0631-6.
  101. Bayramoglu, A., Bayramoglu, G. & Senturk, H. Lycopene partially reverses symptoms of diabetes in rats with streptozotocin-induced diabetes. J. Med. Food (2013) doi:10.1089/jmf.2012.2277.
  102. Renju, G. L., Kurup, G. M. & Kumari, C. H. S. Anti-inflammatory activity of lycopene isolated from Chlorella marina on Type II Collagen induced arthritis in Sprague Dawley rats. Immunopharmacol. Immunotoxicol. (2013) doi:10.3109/08923973.2012.742534.
  103. Eze, E. D. et al. Lycopene Ameliorates Diabetic-Induced Changes in Erythrocyte Osmotic Fragility and Lipid Peroxidation in Wistar Rats. J. Diabetes Mellit. (2017) doi:10.4236/jdm.2017.73006.
  104. Goncu, T. et al. Anti-inflammatory effect of lycopene on endotoxin-induced uveitis in rats. Arq. Bras. Oftalmol. (2016) doi:10.5935/0004-2749.20160102.

International Journal of Scientific Research in Science and Technology

Downloads

Published

2020-08-30

Issue

Volume 7, Issue 4, July-August-2020

Section

Research Articles

License

Copyright (c) IJSRST

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Bharat Kwatra, Md Sadique Hussain, Ratul Bhowmik, Shalini Manoharan , " Reviewing Therapeutic and Immuno-Pathological Applications of Vitamins and Carotenoids, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 7, Issue 4, pp.287-313, July-August-2020. Available at doi : https://doi.org/10.32628/IJSRST207473