Synthesis and Characterization of Pharmaceutical Important Drug S-Xibenlol Very Useful as a Cardiovascular Drug

Authors

  • Mahendra Lokhande  Department of Chemistry, Matoshri Nanibai Gharpalkar Science College, Babhulgaon,Yavatmal, Maharashtra, India
  • Sharad Idhole  Department of Chemistry, Ghulam Nabi Azad Arts, Commerce and Science College, Barshitakli, Akola, Maharashtra, India

Keywords:

Mitsunobu reaction, Spiroketal, Epoxide, Hypertension, Cardiovascular

Abstract

The synthesis of S-Xibanolol was carried out in six step in 34% overall yield. The introduction of chirality was demonstrated by the desymmetrization of glycerol, it results in spiroketal formation with camphorsulfonamide. The Mitsunobu reaction and desymmetrization is the main feature of the reaction. Xibenlol is the alternative drug used in the treatment of hypertension and as cardiotonics.

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International Journal of Scientific Research in Science and Technology

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Published

2018-01-30

Issue

Volume 4, Issue 1, January-February-2018

Section

Research Articles

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How to Cite

[1]
Mahendra Lokhande, Sharad Idhole, " Synthesis and Characterization of Pharmaceutical Important Drug S-Xibenlol Very Useful as a Cardiovascular Drug, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 4, Issue 1, pp.174-176, January-February-2018.