“Synthesis of Some Isoxazolines from Methyl Substituted Acetophenone and Substituted Benzaldehyde Via Chalcone Intermidiate and Their Antimicrobial Studies”

Authors

  • Mayur R. Adokar  Department of Applied Chemistry Anuradha Engineering College, Chikhli, Gujarat, India
  • Mangesh V. Kadu  Department of Applied Chemistry Anuradha Engineering College, Chikhli, Gujarat, India

Keywords:

Isoxazoline, chalcone, antibacterial activity.

Abstract

In this paper new series of Isoxazoline IIa-IIg were prepared by condensation of aromatic Hetrocyclic Chalcones Ia-Ig with hydroxylamine hydrochloride and using Pyridine.The synthesized compounds were characterized by using IRspectra,1H NMR spectra C.H.N analysis. The validity of the expected chemical compounds to the prepared compounds in this search was obvious from IR spectra, 1H NMR spectra and C.H.N.results. It also deals with study of the biological activity of the prepared compounds which showed good to moderate biological activities against various micro organisms (P. aeruginosa, S. aureus, C. frundii, E. coli, P. mirabilis and S. typhi) in comparison to the aromatic Hetrocyclic Chalcones Ia-Ig. Due to their diverse pharmacological activity, it is found useful in the treatment of antibacterial, anticancer, antiproliferative, antifungal, anti-amoebic, anti-inflammatory agents. They also exhibit analgesic, antimicrobial, antitumor and antidepressant activities.

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International Journal of Scientific Research in Science and Technology

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Published

2018-01-30

Issue

Volume 4, Issue 1, January-February-2018

Section

Research Articles

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How to Cite

[1]
Mayur R. Adokar, Mangesh V. Kadu, " “Synthesis of Some Isoxazolines from Methyl Substituted Acetophenone and Substituted Benzaldehyde Via Chalcone Intermidiate and Their Antimicrobial Studies” , International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 4, Issue 1, pp.182-185, January-February-2018.