Synthesis of 3-(2-hydroxy substituted phenyl)-4-(o-methyl benzoyl)-5-(substituted chloro aldehyde) -1-pyridyol pyrazoles

Authors

  • Nitin P. Tayde  Department of Applied Chemistry, Anuradha Engineering College, Chikhli, Navsari, Gujarat, India
  • Mangesh V. Kadu  Department of Applied Chemistry, Anuradha Engineering College, Chikhli, Navsari, Gujarat, India

Keywords:

Abstract

Some new 3-(2-hydroxy substituted phenyl)-4-(o-methyl benzoyl)-5-(substituted chloro aldehyde) -1-pyridyol- pyrazoles (3) have been synthesized by the action of isoniazid on 3-aroyl flavones (2) in pyridine medium. Structures of these compounds have been established by spectral (IR, NMR and UV) and elemental analysis. The compounds were tested for their antimicrobial activities and because of electronegative fluorine atom the compounds showed enhanced antimicrobial activities. Heterocyclic compounds are well known for their wide range of biological applications out of which pyrazoles occupy unique position due to dominant applications. Pyrazoles are important nitrogen-containing five-member ring heterocyclic compounds.

References

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International Journal of Scientific Research in Science and Technology

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Published

2018-01-30

Issue

Volume 4, Issue 1, January-February-2018

Section

Research Articles

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How to Cite

[1]
Nitin P. Tayde, Mangesh V. Kadu, " Synthesis of 3-(2-hydroxy substituted phenyl)-4-(o-methyl benzoyl)-5-(substituted chloro aldehyde) -1-pyridyol pyrazoles, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 4, Issue 1, pp.207-210, January-February-2018.