Cu(Otf)2 Catalyzed Regioselective N3-Arylation Of Biginelli 4-Aryl-3,4-Dihydropyrimidin-2(1H)-One Using Symmetrical Diaryliodonium Salt

Authors(3) :-Nilesh P. Tale, Nitin W. Waghmode, Nandkishor N. Karade

The Biginelli reaction is a simple one pot three-component condensation of an aldehyde, β-ketoester and urea in presence of a catalytic quantity of acid to produce biologically important 3,4-dihydropyrimidin-2-(1H)-ones (DHPMs) scaffolds.1-4 However, the classical Biginelli reaction fails to produce N3-arylated dihydropyrimidones using N-arylurea as one of the reacting component. In this case, N1-arylated DHPMs are obtained as the sole product.12 Therefore; there is a necessity to perform N3-arylation of DHPMs to furnish decorated cyclic urea analogues.

Authors and Affiliations

Nilesh P. Tale
Late B. S. Arts, Prof. N. G. Science and A. G. Commerce college Sakharkherda. Tq. Sindkhed Raja. ,Buldhana, Maharashtra, India
Nitin W. Waghmode
Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India
Nandkishor N. Karade
Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India

Aldehyde, β –Ketoester, Urea.

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  8. Kappe, C. O. Liebigs Ann. Chem. 1990, 505.

Publication Details

Published in : Volume 4 | Issue 1 | January-February 2018
Date of Publication : 2018-01-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 388-390
Manuscript Number : IJSRST4196
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Nilesh P. Tale, Nitin W. Waghmode, Nandkishor N. Karade, " Cu(Otf)2 Catalyzed Regioselective N3-Arylation Of Biginelli 4-Aryl-3,4-Dihydropyrimidin-2(1H)-One Using Symmetrical Diaryliodonium Salt", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 4, Issue 1, pp.388-390, January-February-2018.
Journal URL : https://ijsrst.com/IJSRST4196
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