Regulation of Collagen Synthesis in Tobacco/Pan-Masala Induced Oral Sub-Mucosal Fibrosis and Diagnostic Approach - Review Article

Authors

  • Shraddha Awasthi  Department of Pathology, ERA University, Sarfarazganj, Hardoi Road, Lucknow, Uttar Pradesh, India
  • Ausaf Ahmad  Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, Uttar Pradesh, India
  • Anand Narain Srivastava  Department of Pathology, ERA University, Sarfarazganj, Hardoi Road, Lucknow, Uttar Pradesh, India

DOI:

https://doi.org//10.32628/IJSRST218114

Keywords:

Oral Sub-Mucosal Fibrosis, Oral Potentially Malignant Lesion Diagnosis, Collagen Synthesis.

Abstract

Introduction : oral submucosal fibrosis (OSMF) is related to juxta epithelial inflammatory response followed by a fibroelastic change of the lamina propria, with epithelial atrophy leading to stiffness of the oral mucosa, causing trismus and inability to eat.

Methods and Materials: The suitability standards for studies were: Research Articles that studied the metabolic activities in oral submucous fibrosis mainly caused by some carcinogenic substances or chemicals which may present in tobacco, alcohol, cigarettes, pan-masala etc Reference list of selected articles and reviews on the topic also were searched. studies were extracted, A total of 90-100 studies were extracted, using the keywords oral submucous fibrosis, oral potentially malignant lesion and diagnosis, collagen synthesis etc.,

Results: cancer risk among these patients, periodic biopsies of suspicious regions of the oral mucosa are essential for the early detection and management of high?risk oral premalignant lesions and prevention of cancer.

Conclusion: OSMF is hardly recognized and is poorly understood across the globe. significant improvement in management, nor reduction in its high malignant transformation rate. Better integration of medical and dental services, especially in developing countries, may reduce patients’ suffering and improve their life quality.

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2021-02-28

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Volume 8, Issue 1, January-February-2021

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[1]
Shraddha Awasthi, Ausaf Ahmad, Anand Narain Srivastava, " Regulation of Collagen Synthesis in Tobacco/Pan-Masala Induced Oral Sub-Mucosal Fibrosis and Diagnostic Approach - Review Article, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 8, Issue 1, pp.134-143, January-February-2021. Available at doi : https://doi.org/10.32628/IJSRST218114