Synthesis, Characterization and Biological Evaluation of Some Pyrrole Derivatives as Potential Antimicrobial Agents

Authors

  • Safiya R. Shaikh  Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Dist-Sangli, Maharashtra, India-415404
  • Hanmant S. Mali  Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Dist-Sangli, Maharashtra, India-415404
  • Shubhangi S. Thorat  Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Dist-Sangli, Maharashtra, India-415404
  • Vishwajit D. Dhaygude  Department of Quality Assurance, Tatyasaheb Kore College of Pharmacy, Warananagar, Dist-Kolhapur, Maharashtra, India
  • Muskan M. Bhaldarakar  Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Dist-Sangli, Maharashtra, India-415404
  • Akshay R. Yadav  Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Dist-Sangli, Maharashtra, India-415404

DOI:

https://doi.org//10.32628/IJSRST2183150

Keywords:

Pyrrole derivatives, Characterization, Biological Evaluation, Antimicrobial activity.

Abstract

Novel series of pyrrole derivatives were synthesized with an approach to develop more potent and less side effects having antimicrobial activity. An efficient synthesis of different novel 2-methyl-7(4-nitrophenyl)-5,6-diphenyl-3,7-dihydro-4H-pyrrolo-[2,3-d]pyridine-4-one derivatives by the Paal-knorr Condensation. Benzoin with primary aromatic amines refluxing in ethanol resulted the formation of α-aminoketone intermediates, which were condensed, without isolation, with malononitrile to yield the various 2-amino-4,5-diphenyl-1-substituted-1H-pyrrole-3-carbonitriles (Ia-e). Pyrrole (Ia-e) further reacted with acid such as acetic acid to yield compound (IIa-e). The synthesized compounds were confirmed through spectral characterization using IR, Mass and 1H NMR. Result indicated that these compounds showed promising antimicrobial activity by comparing to standard drugs.

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International Journal of Scientific Research in Science and Technology

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Published

2021-06-30

Issue

Volume 8, Issue 3, May-June-2021

Section

Research Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Safiya R. Shaikh, Hanmant S. Mali, Shubhangi S. Thorat, Vishwajit D. Dhaygude, Muskan M. Bhaldarakar, Akshay R. Yadav, " Synthesis, Characterization and Biological Evaluation of Some Pyrrole Derivatives as Potential Antimicrobial Agents, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 8, Issue 3, pp.757-770, May-June-2021. Available at doi : https://doi.org/10.32628/IJSRST2183150