Raman Spectroscopic Technique for Cancer Diagnosis

Authors

  • Patil S A  P. R. Pote College of Engineering and Management, Amravati, Maharashtra, India
  • Thakare N R  P. R. Pote College of Engineering and Management, Amravati, Maharashtra, India
  • Bhoyar A D  P. R. Pote College of Engineering and Management, Amravati, Maharashtra, India

Keywords:

Raman Spectra, Cancer, Molecular Change

Abstract

Raman Spectroscopic technique can be applied for the cancer diagnosis as it can probe the molecular changes associated with diseased tissue. The molecular and cellular changes occurring in the disease result in distinct Raman Spectra. We have recorded the Raman Spectra of 4 samples at different positions. The Raman features and intensity differs for normal and malignant cells which can be attributed to the variation in the chemical composition of the cells.

References

  1. Lam S, Kennedy T, Urger M. Miller YE, Germont D, Rusch V, “Localization of bronchial intraepithelial neoplastic usionsty fluorescence bronchioscopy”, (1998)
  2. Hung J, Lam S, Le Riche JC, Palcic B, “Autofluorence of normal and Malignant bronchial tissue, Laser Surg.” Med. (1991)
  3. Peno JR, Grygon CA, Spiro TG, “Raman Excitation Profiles for the nucleotides and for the nudlic acid duplexes poly (rA)-poly (rU) and poly (dG-dC) J. Physchon” (1989) V93.
  4. Tu AT, Peptide backbone conformation and microenvironment of Pritein side chain. “Spectroscopy of biological Systems”, New York John Willey and Sons, (1986)
  5. Frank CJ, McCreery R/s, Redd-DC, Raman Spectroscopy of normal and diseased human breast tissues. Anal Chem. 1995, 67.
  6. Manocharan R, Shafer K, Perelmon L, Wu J, Chen K, Denium G, Fitzmarice M, Myles J, Crowe J, Darari R, Fold MS, “Raman Spectroscopy and fluorescence photon migration for breast cancer diagnosic and imaging” Photochem Photobio, (1998), 67, 15-22.
  7. Schrader B, Keller S, Loechte T, Fendels, Moore DS, Simon A, Sawatzki J., NIRFT Raman Spectroscopy in medical diagnosis. J. Mol Struct (1995), DP 348-293-6.
  8. Mahadevan-Jansen A, Mitchell MF, Ramanujan N, Malpica A, Thomsen S, Utzinger J, Richard Kortum R. Near infrared Raman spectroscopy for in vitro detection of cervical precanars. Photochem Photobio. (1998) 68.
  9. Lau DP, Hang Z, Luitl, MonCS, Poerean K, Morrison MD, Zeng H, “Raman spectroscopy for early detection of laryngeal malignancy : preliminary result, Laryngoscope (2000), 110.
  10. Alfano RR, Liu CH, Sha WL, Zhu D, Akins L, “Human breast tissues studied by IR Flowerer transform Raman Spectroscopy” Lasers Life Sci.(1991).
  11. Mahadevan Gansen A, Richards Kortum R, “Raman Spectroscopy for the detection of cancer and precancer “J Biomed Opt. (1996).
  12. Shafer-Pettier, K.E. Haka, A.S. Fitzmauria, M, Crowe J., Myles J., Dasari R.R. and Feld M.S. “Raman Micro spectroscopic model of human breast tissue, implications for breast cancer diagnosis in vivo”, J.Raman Spectros. 33 (2002).
  13. Stone N., Kendall C., Shepherd N., Crow P., Bars H., “Near-infrared Raman Spectroscopy for the classification of epithelial pre-can as and cancers”, J.Raman Spectrosc, 33, 564, 2002.
  14. Utginger U., Heintzelman D.L., Mahadevan Gansen A., Malpica A., Follen M. and Richards Kortum, “NTR spectroscopy for in vivo detection of cervical precancers”, Appl. spectrosc. 55, 955 (2001).
  15. Nijssen A, Bakker Schut, T.C. Heuls F., Caspers P.J., Hayes D.P., Neumann M.H., and Puppels G.J., “Discriminating basal cell carcinoma from its surrounding tissue by Raman spectroscopy, J.Invest. Dermatot, 119, 64, 2002.
  16. Trans R.C.M, McCrery R.L. and Redd D.C. “Raman spectroscopy of normal and diseased human breast tissues, “Anal.Chem, 67, 777, 1995.

Downloads

Published

2021-04-15

Issue

Section

Research Articles

How to Cite

[1]
Patil S A, Thakare N R, Bhoyar A D "Raman Spectroscopic Technique for Cancer Diagnosis" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 9, Issue 4, pp.137-146, March-April-2021.