A One-Pot Synthesis of 1,4-dihydropyrimido[1,2-a] benzimidazoles and their Antimicrobial Activity

Authors

  • Kalpesh V. Vilapara  Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
  • Rajendra M. Jadav  Department of chemistry, Bhavan’ssheth R. A. college of science, Ahmedabad, Gujarat, India
  • Sagar P. Gami  Department of chemistry, Bhavan’ssheth R. A. college of science, Ahmedabad, Gujarat, India

Keywords:

Pyrimidine, Benzimidazole, Cyclocondensation, Antimicrobial

Abstract

A one-pot synthesis of 1,4-dihydropyrimido[1,2-a]benzimidazole were carried out by Biginelli like cyclocondensation of aromatic aldehydes and acetoacetic acid derivatives with 2-amino benzimidazole containing a guanidine fragment. The newly synthesized compounds were characterized by IR, NMR and Mass spectroscopy.

References

  1. Abdelhamid, A. O.; Abdelall, Eman K. A.; Abdel-Riheem, Nadia A.; Ahmed, Sayed A. Phosphorus, Sulfur and Silicon2010, 185, 709.
  2. Shaabani, M. R. Heterocycles2008, 75, 3005. 
  3. Werbel, L. M.; Curry, A.; Elslager, E. F.; Hess, C. A.; Hutt, M. P.; Youngstrom, C. Journal of Heterocyclic Chemistry1969, 6, 787.
  4. Nawrocka, W. P.; Sztuba, B.; Drys, A.; Wietrzyk, J.; Kosendiak, J.; Opolski, A. Polish Journal of Chemistry2006, 80, 279.
  5. Sondhi, S. M.; Magan, A.; Sahu, R.; Mahesh, V. K.; Shukla, R.; Patnaik, G. K. Synthesis 1994, 11, 1175.
  6. Srinivasan, N., Balaji A., Nagrajan, G., Suthakaran, R., Kumar, Y. ;Asian J. Chem., 2008, 20, 4934.
  7. Berg, D., Büchel, K. H., Plempel, M., Zywietz, A.; Mycoses, 1986, 29, 221.
  8. Leonard, J. T.; Jeyaseeli, L., Kumar, M., Sivakumar, R.; Asian J. Chem., 2006, 18, 1104.
  9. Orjales, A., Cires, L. A., Tudanca, P. L., Tapia, I., Mosquera, R., Labeaga, L.; Eur. J. Med. Chem., 1999, 34, 415.
  10. Wahe, H.; Asobo, P. F.; Cherkasov, R. A.; Nkengfack, A. E.; Folefoc, G. N.; Fomum, Z. T.; Doepp, D. Arkivoc2003, 14, 170.
  11. Kumar, B. B., Rao, P. V. ;Asian J. Chem., 2006, 18, 3060..
  12. Shaabani, A.; Rahmati, A.; Naderi, S. Bioorg. Med.Chem. Lett.2005, 15, 5553.
  13. Yao, C.; Lei, S.; Wang, C.; Yu, C.; Shao, Q.; Tu, S..Chin. J. Chem. 2008, 26, 2107. 
  14. Shaabani, A.; Rahmati, A.; Rezayan, A. H.; Darvishi, M.; Badri, Z.; Sarvari, A. QSAR & Combinatorial Science 2007, 26, 973.
  15. Tu, S.; Shao, Q.; Zhou, D.; Cao, L.; Shi, F.; Li, C..J. Heterocycl. Chem. 2007, 44, 1401.
  16. Gladkov, E. S.; Chebanov, V. A.; Desenko, S. M.; Shishkin, O. V.; Shishkina, S. V.; Dallinger, D.; Kappe, C. O., Heterocycles 2007, 73 469.
  17. Nofal, Z. M.; Fahmy, H. H.; Mohamed, H. S. Arch.Pharm. Res.2002, 25, 28.
  18. Abdelhamid, A. O.; Riad, B. Y.; Aziz, S. I. Fac. Sci., Cairo Univ., Giza, Egypt. Arch.Pharm. 1987, 320, 642.

International Journal of Scientific Research in Science and Technology

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Published

2018-02-28

Issue

Volume 3, Issue 7, September-October-2017

Section

Research Articles

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How to Cite

[1]
Kalpesh V. Vilapara, Rajendra M. Jadav, Sagar P. Gami "A One-Pot Synthesis of 1,4-dihydropyrimido[1,2-a] benzimidazoles and their Antimicrobial Activity" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 3, Issue 7, pp.1204-1210 , September-October-2017.