Therapeutic Potentials and Applications of Folic Acid and Beta Carotene

Authors

  • Bharat Kwatra  Invenzion labs
  • Rachit Modi  B. S. Anangpuria Institute of Pharmacy, Delhi-NCR, India

DOI:

https://doi.org/10.32628/IJSRST1207481

Keywords:

Therapeutic, Bioactive, Folic Acid, Folate Deficiency

Abstract

The present review is based mainly on papers published between 2000 and 2020 and gives information about the properties of the Folic Acid and Beta Carotene in chemical and biological systems and its possible role in preventing several diseases. The main aim of this report is to highlight its role as an immunopathological applications, also reported are bioactive properties that may influence the development of foam cells and protection against endothelial cell damage.

References

  1. Luterotti, S., Bicanic, D., Marković, K. & Franko, M. Carotenes in processed tomato after thermal treatment. Food Control 48, (2015).
  2. Butler, N. & Ghugre, P. Effect of beta carotene on the ionisable iron content of wheat. Curr. Res. Nutr. Food Sci. 8, (2020).
  3. Extraction and Analysis of Beta-carotene Recovery in CPO and Oil Palm Waste by Using HPLC. ARPN J. Eng. Appl. Sci. 11, (2016).
  4. Qin, Y., Woo, H. J., Shin, K. S., Lim, M. H. & Lee, S. K. Comparative transcriptome profiling of different tissues from beta-carotene-enhanced transgenic soybean and its non-transgenic counterpart. Plant Cell. Tissue Organ Cult. 140, (2020).
  5. Druesne-Pecollo, N. et al. Beta-carotene supplementation and cancer risk: A systematic review and metaanalysis of randomized controlled trials. Int. J. Cancer 127, (2010).
  6. Donhowe, E. G. & Kong, F. Beta-carotene: Digestion, Microencapsulation, and In Vitro Bioavailability. Food and Bioprocess Technology vol. 7 (2014).
  7. Avraham, Y. et al. Beta-carotene as a novel therapy for the treatment of “Autistic like behavior” in animal models of Autism. Behav. Brain Res. 364, (2019).
  8. Huang, J., Weinstein, S. J., Yu, K., Männistö, S. & Albanes, D. Serum beta carotene and overall and cause-specific mortality: A prospective cohort study. Circ. Res. 123, (2018).
  9. Li, Q., Sun, Z., Li, J. & Zhang, Y. Enhancing beta-carotene production in Saccharomyces cerevisiae by metabolic engineering. FEMS Microbiology Letters vol. 345 (2013).
  10. Bonnefond, H. et al. Coupling and uncoupling of triglyceride and beta-carotene production by Dunaliella salina under nitrogen limitation and starvation. Biotechnol. Biofuels 10, (2017).
  11. Ding, Y. X. & Cui, H. Effects of Folic Acid on DNMT1, GAP43, and VEGFR1 in Intrauterine Growth Restriction Filial Rats. Reprod. Sci. 25, (2018).
  12. Wang, F., Wang, Y., Ma, Q., Cao, Y. & Yu, B. Development and characterization of folic acid-conjugated chitosan nanoparticles for targeted and controlled delivery of gemcitabinein lung cancer therapeutics. Artif. Cells, Nanomedicine Biotechnol. 45, (2017).
  13. Naim, M. Y. et al. Folic acid enhances early functional recovery in a piglet model of pediatric head injury. Dev. Neurosci. 32, (2011).
  14. Bwatanglang, I. B. et al. Folic acid targeted Mn:ZnS quantum dots for theranostic applications of cancer cell imaging and therapy. Int. J. Nanomedicine 11, (2016).
  15. Chalupsky, K., Kračun, D., Kanchev, I., Bertram, K. & Görlach, A. Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase. Antioxidants Redox Signal. 23, (2015).
  16. Fischer, F. et al. Folic acid and creatine improve the firmness of human skin in vivo. J. Cosmet. Dermatol. 10, (2011).
  17. Yang, S. et al. Non-covalent complexes of folic acid and oleic acid conjugated polyethylenimine: An efficient vehicle for antisense oligonucleotide delivery. Colloids Surfaces B Biointerfaces 135, (2015).
  18. Rana, S. et al. Folic acid conjugated Fe3O4 magnetic nanoparticles for targeted delivery of doxorubicin. Dalt. Trans. 45, (2016).
  19. Lv, T. et al. Role of generation on folic acid-modified poly(amidoamine) dendrimers for targeted delivery of baicalin to cancer cells. Mater. Sci. Eng. C 75, (2017).
  20. Carron, P. M. et al. Targeting the Folate Receptor: Improving Efficacy in Inorganic Medicinal Chemistry. Curr. Med. Chem. 25, (2018).
  21. Qiu, J. et al. The antitumor effect of folic acid conjugated-Auricularia auricular polysaccharide-cisplatin complex on cervical carcinoma cells in nude mice. Int. J. Biol. Macromol. 107, (2018).
  22. Wang, X. et al. Preparation of Folic Acid-Targeted Temperature-Sensitive Magnetoliposomes and their Antitumor Effects In Vitro and In Vivo. Target. Oncol. 13, (2018).
  23. Tian, Y. et al. Folic acid-targeted etoposide cubosomes for theranostic application of cancer cell imaging and therapy. Med. Sci. Monit. 23, (2017).
  24. Kapoor, M. S. et al. Stable Liposome in Cosmetic Platforms for Transdermal Folic acid delivery for fortification and treatment of micronutrient deficiencies. Sci. Rep. 8, (2018).
  25. Feng, R. et al. Y-shaped Folic Acid-Conjugated PEG-PCL Copolymeric Micelles for Delivery of Curcumin. Anticancer. Agents Med. Chem. 17, (2016).
  26. Chiani, M. et al. Folic acid conjugated nanoliposomes as promising carriers for targeted delivery of bleomycin. Artif. Cells, Nanomedicine Biotechnol. 46, (2018).
  27. Stallivieri, A., Baros, F., Jetpisbayeva, G., Myrzakhmetov, B. & Frochot, C. The Interest of Folic Acid in Targeted Photodynamic Therapy. Curr. Med. Chem. 22, (2015).
  28. Czeizel, A. E., Dudás, I., Vereczkey, A. & Bánhidy, F. Folate deficiency and folic acid supplementation: The prevention of neural-tube defects and congenital heart defects. Nutrients vol. 5 (2013).

International Journal of Scientific Research in Science and Technology

Downloads

Published

2020-08-30

Issue

Volume 7, Issue 4, July-August-2020

Section

Research Articles

License

Copyright (c) IJSRST

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Bharat Kwatra, Rachit Modi "Therapeutic Potentials and Applications of Folic Acid and Beta Carotene" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 7, Issue 4, pp.271-282, July-August-2020. Available at doi : https://doi.org/10.32628/IJSRST1207481