Study of Pharmacophoric Consensus Pattern for Benzoic Acid Derivatives of 1,3,4-Thiadiazole As Antibacterial Agent

Authors

  • C. N. Jadhav  Research Scholar, Vidya Bharati Mahavidyalaya, Amravati, Maharashtra, India
  • M. M. Rathore  Professor & Head, Department of Chemistry, Vidya Bharati Mahavidyalaya, Amravati, Maharashtra, India
  • V. H. Masand  Professor, Department of Chemistry, Vidya Bharati Mahavidyalaya, Amravati, Maharashtra, India
  • P. S. Bodkhe  Associate Professor, Department of Chemistry, Vidya Bharati Mahavidyalaya, Amravati, Maharashtra, India

DOI:

https://doi.org/10.32628/IJSRST1231011

Keywords:

1,3,4-Thiadiazole, Pharmacophore Modeling, Antifungal, Antibacterial, Lipophilic, H-Bond Acceptor, H-Bond Donor.

Abstract

Microbial infections have targeted millions of victims in human history. In spite of the great efforts that are being continuously made to find effective medication, still no drug exists that can truly cure and have no side effects for the said infections. Amongst the drugs that are available in the market for microbial infections, 1,3,4-thiadiazole derivatives have found to have extensive pharmacological activities and further optimized for other diseases [1,2]. Efforts are done to synthesize various carboxylic acid derivatives of 1,3,4 thiadiazol and to study their pharmacological activities [1,2]. In this research article, comparative study of various previously synthesized carboxylic acid derivatives of 1,3,4 thiadiazol is done using their pharmacophore modeling to identify the prominent structural features [1]. The analysis indicates that the synthesized molecules have specific hydrogen acceptor, hydrogen donor and lipophilic centers with some variations.

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International Journal of Scientific Research in Science and Technology

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Published

2023-02-28

Issue

Volume 10, Issue 1, January-February-2023

Section

Research Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
C. N. Jadhav, M. M. Rathore, V. H. Masand, P. S. Bodkhe "Study of Pharmacophoric Consensus Pattern for Benzoic Acid Derivatives of 1,3,4-Thiadiazole As Antibacterial Agent" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 10, Issue 1, pp.167-174, January-February-2023. Available at doi : https://doi.org/10.32628/IJSRST1231011