Assay of Clopidogrel by Using HPLTC Method

Authors

  • Dr. D. S. Ghotekar  Department of Chemistry, N.V.P.Mandal's, Arts, Commerce and Science College Lasalgaon, Tal-Niphad, Dist-Nashik, Maharastra, India
  • Vishal N. Kushare  Department of Pharmaceutics, Maratha Vidya Prasarak Samaja's Institute of Pharmaceutical Sciences, Adgaon, Nashik, Maharastra, India

DOI:

https://doi.org/10.32628/IJSRST12848252

Keywords:

Clopidogrel, Validation, HPTLC

Abstract

The present paper describes stability indicating high-performance thin-layer chromatography (HPTLC) assay method for clopidogrel in bulk drugs. The method employed TLC aluminium plates precoated with silica gel 60F-254 as the stationary phase. The solvent system consisted of toluene: methanol: triethylamine (6.5: 4.0: 0.1 v/v/v). The system was found to give compact spot for clopidogrel (Rfvalue of 0.40 ± 0.010). Densitometric analysis of Clopidogrel was carried out in the absorbance mode at 254 nm. The linear regression analysis data for the calibration plots showed good linear relationship with r2 = 0.888 with respect to peak area in the concentration range 30 - 120 ng/spot.

References

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  4. Sonia K, Beddi Bhavya shree, Dr.K.S.Lakshmi, "HPTLC Method Development and Validation: An Overview", J. Pharm. Sci. & Res. Vol. 9(5), 2017,652-657
  5. Vishal N. Kushare, Sachin S Kushare, Development of Validated Stability Indicating HPTLC Method for Assay of Ozagrel and its Pharmaceutical Formulations, International Journal of Scientific Research in Science, Engineering and Technology. November- December-2018 4 (11): 36-48]
  6. Vishal N. Kushare, Sachin S Kushare, Sagar V Ghotekar, Development of Validated UV Spectrophotometric Method for Assay ofOzagrel and its Pharmaceutical Formulations. International Journal of Scientific Research in Science, Engineering and Technology. November-December-2018 4 (11): 69-77]

International Journal of Scientific Research in Science and Technology

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Published

2018-01-23

Issue

Volume 4, Issue 11, November-December-2018

Section

Research Articles

License

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Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Dr. D. S. Ghotekar, Vishal N. Kushare "Assay of Clopidogrel by Using HPLTC Method" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 4, Issue 11, pp.409-413, November-December-2018. Available at doi : https://doi.org/10.32628/IJSRST12848252