Ion Channels Association with Diseases and their Role as Therapeutic Targets in Drug Discovery

Authors

  • Mahin Ghorbani  Department of Biotechnology, Fergusson College, F.C. Road, Pune, Maharashtra 411004, India
  • Hamed Karimi   Department of Information Technology, Payam noor university of Farokh-shahr , Farokh-shahr, Chaharmahl va bakhtiari, Iran

Keywords:

Ion channel, target, drug discovery, pathology. Modulation of Ion channels

Abstract

Ion channels as potential drug targets has been widely designated in pharmaceutical industries for treatment of life threatening diseases .This targeting is a challenging area in drug development and discovery because of availability of extensive knowledge of structures and functions about ion channels such as sodium and calcium voltage-gated ion channels found in mammals. These knowledge mostly obtained on the basis of 3-D crystallographic studies along with their computational analysis. Analysis and modulation of Ion channels provide us with understanding of various properties, such as channel opening, pore function, voltage sensing and ion selectivity. Any disruption and dysregulation in the mentioned functions leads to pathological states thus supporting the idea of their choice as valid targets in drug discovery projetcs.In this paper we focused on importance of ion channels in drug discovery and reviewed their structures and functions and their role in disease and drug discovery and their modulation technologies in drug discovery for their targeting purpose.

References

  1. Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Catterall WA, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Ion Channels. Br J Pharmacol. 170: 1607-1651.
  2. Rastogi .S. C., Rastogi P and Mendiratta N.,2008. Bioinformatics Methods and Applications Genomics.Proteomics And Drug Discovery PHI Learning Pvt. Ltd
  3. Armstrong CM (1992) Voltage-dependent ion channels and their gating. Physiol Rev 72(4 Suppl): S5-S13. Review.
  4. Gouaux E, Mackinnon R (2005) Principles of selective ion transport in channels and pumps. Science 310: 1461-1465.
  5. Hille B (2001) Ion Channels of Excitable Membranes, 3rd Ed. Sinauer Associates, Sunderland, Mass. 6 .Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117: 500-544.
  6. Arcangeli A, Wanke E, Olivotto M, Camagni S, Ferroni A. Three types of ion channels are present on the plasma membrane of Friend erythroleukemia cells. Biochem Biophys Res Commun. 1987 Aug 14;146(3):1450-7.
  7. Felix, J.P., B.S. Williams, B.T. Priest, R.M. Brochu, I.E. Dick, V.A. Warren, L. Yan, R.S. Slaughter, G.J. Kaczorowski, M.M. Smith, and M.L. Garcia. 2004. Functional assay of voltage-gated sodium channels using membrane potential-sensitive dyes. Assay Drug Dev. Technol. 2:260-268.
  8. Garcia, M.L., and G.J. Kaczorowski. 2001. Pharmacology of high-conductance, Ca2+- Williams, B.S., J.P. Felix, B.T. Priest, R.M. Brochu, K. Dai, S.B. Hoyt, C. London, Y.S. Tang, J.L. Duffy, W.H. Parsons, et al. 2007. Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7. Biochemistry. 46:14693-14703
  9. Activated potassium channels. In Potassium Channels in Cardiovascular Biology. A.A. Rusch, editor. Academic/Plenum Publishers, New York. 219-234.
  10. Garcia, M.L., and G.J. Kaczorowski. 2005. Potassium channels as targets for therapeutic intervention. Sci. STKE. 2005:pe46
  11. Garcia, M.L., D.-M. Shen, and G.J. Kaczorowski. 2007. High-conductance calcium-activated potassium channels: validated targets for smooth muscle relaxants? Expert Opin. Ther. Patents. 17:832-842.
  12. Hille B. Ionic channels of excitable membranes (2nd ed.).Sunderland, MA: Sinauer AssociatesInc. 1992.
  13. MacKinnon R. X-ray structure of a voltage-dependent K+ channel. Nature 2003;423:33-41
  14. Bagal SK, Brown AD, Cox PJ, Omoto K, Owen RM, Pryde DC, Sidders B, Skerratt SE, Stevens EB, Storer RI, Swain NA.Ion channels as therapeutic targets: a drug discovery perspective. J Med Chem. 2013 Feb 14;56(3):593-624.
  15. Gregory J. Kaczorowski, Owen B. McManus, Birgit T. Priest, and Maria L. Garcia Ion Channels as Drug Targets: The Next GPCRs. J Gen Physiol. 2008 May; 131(5): 399-405.
  16. A.M Waszkielewicz,* A Gunia, N Szkaradek, K S?oczy?ska, S Krupi?ska, and H Marona Ion Channels as Drug Targets in Central Nervous System Disorders Curr Med Chem. 2013 Apr; 20(10): 1241-1285
  17. Sharan K. Bagal, Alan D. Brown , Peter J. Cox , Kiyoyuki Omoto , Robert M. Owen , David C. Pryde*, Benjamin Sidders, Sarah E. Skerratt , Edward B. Stevens, R. Ian Storer , and Nigel A. Swain Ion Channels as Therapeutic Targets: A Drug Discovery Perspective. J. Med. Chem., 2013, 56 (3), pp 593-624
  18. Levitan IB1. Modulation of ion channels by protein phosphorylation and dephosphorylation. Annu Rev Physiol. 1994;56:193-212.
  19. Tabassum N, Feroz A Ion Channels and their Modulation Journal of Applied Pharmaceutical Science 01 (01); 2011: 20-25

International Journal of Scientific Research in Science and Technology

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Published

2015-08-25

Issue

Volume 1, Issue 3, July-August-2015

Section

Research Articles

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How to Cite

[1]
Mahin Ghorbani, Hamed Karimi , " Ion Channels Association with Diseases and their Role as Therapeutic Targets in Drug Discovery, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 1, Issue 3, pp.65-69, July-August-2015.