Comparative Formulation and Evaluation of Fast Dissolving Candesartan Tablet Using Natural Superdisintegrants

Authors

  • Swati S. Talokar  Rajarambapu College of Pharmacy, Kasegaon. Tal-Walwa Dist Sangli, Maharashtra, India
  • Rohan R Vakhariya  Rajarambapu College of Pharmacy, Kasegaon. Tal-Walwa Dist Sangli, Maharashtra, India
  • Archana R. Dhole  Rajarambapu College of Pharmacy, Kasegaon. Tal-Walwa Dist Sangli, Maharashtra, India

Keywords:

Candesartan celixitil, superdisintegrants, starch glycolate, plantago ovate

Abstract

Candesartan is used commonly for the treatment of hypertension. It has half-life of 9 hrs whereas T max is 3-4 hr. As Candesartan is water insoluble drug this adversely affects bioavailability and bioequivalence.In present study efforts are made to reduce its disintegrating time using Plantago ovata and Sodium starch glycolate as comparative superdisintegrnats.. The objective of the present study was to prepare the fast dissolving tablet of candesartan using different natural superdisintegrants like Plantago ovata, , Sodium Starch Glycolate, . Hardness, friability, weight variation, wetting time, thickness, water absorption ratio, disintegrating time, uniformity of content and in-vitro drug release were checked for evaluation purpose.

References

  1. Vaibhav N. Nagre*, Omprasad S.Niyakal, Archana R.Dhole, C.S. Magdum Formulation and Evaluation of Fast Dissolving Tabletes of Candesartan using Natural Excipients for the Treatment of Hypertension 2015 IJSRST | Volume I pg.no.170
  2. Basawaraj S.Patil1*, N.G.Raghavendra Rao2 Formulation and Evaluation of fast dissolving tablets of candesartan cilexetil using natural and synthetic superdisintegrants 250 | J App Pharm 03(03): 250-261 (2011)
  3. *Harish Gopinath3, Kasi Sankar Venugopal1, Disintegrants- a brief review

International Journal of Scientific Research in Science and Technology

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Published

2017-12-31

Issue

Volume 2, Issue 3, May-June-2016

Section

Research Articles

License

Copyright (c) IJSRST

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Swati S. Talokar, Rohan R Vakhariya, Archana R. Dhole "Comparative Formulation and Evaluation of Fast Dissolving Candesartan Tablet Using Natural Superdisintegrants" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 2, Issue 3, pp.206-211, May-June-2016.