Synthesis, Molecular Structure and Antibacterial Activity of Benzylmethyl-4-Methyl-3-Thiosemicarbazone

Authors

  • Shirisha Alle  Department of Organic Chemistry, Arts and Science College, Subedari, Hanamkinda, Telangana, India

Keywords:

Benzylmethyl-4-Methyl-3-Thiosemicarbazone, Antibacterial Activity, Crystal Structure

Abstract

A novel Schiff base, benzylmethyl-4-methyl-3-thiosemicarbazone (BMM) derived from benzylmethylketone and 4-methylthiosemicarbazide was synthesized and characterized by elemental analysis, spectroscopic methods (IR, 1H NMR, 13C NMR) and physical means. The single crystal structure analysis of the Schiff base reveals that it crystallizes in a monoclinic system in the P21/c space group. BMM revealed moderate antibacterial activity on three bacterial strains with diameter zone of inhibition of 16 mm (E. coli), 14 mm (K. pneumonia ) and 13 mm (S. epidermidis ) compared with the standard drug, ciprofloxacin.

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International Journal of Scientific Research in Science and Technology

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Published

2017-12-31

Issue

Volume 3, Issue 8, November-December-2017

Section

Research Articles

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How to Cite

[1]
Shirisha Alle "Synthesis, Molecular Structure and Antibacterial Activity of Benzylmethyl-4-Methyl-3-Thiosemicarbazone" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 3, Issue 8, pp.650-656, November-December-2017.