A Process for Preparation of 2-[6-substituted-[1,2,4]-triazolo[3,4-b] [1,3,4] thiadiazole-3-yl]phenol and it's Antimicrobial Activity

Authors

  • Ramesh N. Patel  Department of Chemistry Municipal Arts and Urban Bank Science College, Mehsana, Gujarat, India
  • Vipul B. Audichya  Department of Chemistry Municipal Arts and Urban Bank Science College, Mehsana, Gujarat, India
  • Kantilal S. Patel  Department of Chemistry Municipal Arts and Urban Bank Science College, Mehsana, Gujarat, India

Keywords:

[1,2,4]-triazolo[3,4-b ][1,3,4]thiadiazole-3-yl] Phenol, Antimicrobial Evaluation

Abstract

A STTP promoted series of compound 2-[6-substituted-[1,2,4]-triazolo[3,4-b][1,3,4]thiadiazole-3-yl]phenol(3a-j) was synthesis by 4-Amino-5-mercapto-4H-1,2,4-triazole (1) (0.1mole) and,Various acid derivatives (2a-j) in presence of phosphorous oxychloride (100 ml) in alcoholic solvent was heated at reflux temp for 6-8 hrs. This procedure is compatible with a broad range of functional groups describe R1 = various amide derivative afforded good yield 72-85% in suitable alcoholic solvent and excess of phosphorus oxychloride was removed under vacuum in presence of alcohol solvent. The Product STPP (3a-j) purification done by acid base treatment and recrystlaistion in alcohol to give highly pure compound ; 2-[6-substituted-[1,2,4]-triazolo[3,4-b][1,3,4]thiadiazole-3-yl]phenol (3a-j).

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International Journal of Scientific Research in Science and Technology

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Published

2017-12-28

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Volume 3, Issue 8, November-December-2017

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Research Articles

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[1]
Ramesh N. Patel, Vipul B. Audichya, Kantilal S. Patel "A Process for Preparation of 2-[6-substituted-[1,2,4]-triazolo[3,4-b] [1,3,4] thiadiazole-3-yl]phenol and it's Antimicrobial Activity" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 3, Issue 8, pp.1204-1211, November-December-2017.