Synthesis and Antifungal Studies of New Metal Complexes of 1, 3, 4-Oxadiazole derivatives (CODMHQ)

Authors

  • RajeshKumar A. Chauhan  Sheth L. H. Science College, Mansa, Gujarat, India
  • Kaushik A. Joshi  D K V Arts & Science College, Jamnagar, Gujarat, India
  • Ninad Bhatt  D K V Arts & Science College, Jamnagar, Gujarat, India
  • Dr. G. D. Acharya  R. R. Mehta Science College, Palanpur, Gujarat, India

Keywords:

5-((4-chlorophenoxy)methyl)-3-(((8-hydroxyquinolin-5-yl)amino)methyl)-1,3,4-oxadiazole-2(3H)-thione, Spectroscopies study, Magnetic moment, Antifungal properties.

Abstract

Mannich reaction between 5-amino-8-quinolinol (AMQ) and 5-(4-chloro phenoxy methyl acetyl)-1,3,4-oxadiazole-2(3H)-thione (POD) in the presence of formaldehyde was gave 5-((4-chlorophenoxy)methyl)-3-(((8-hydroxyquinolin-5-yl)amino)methyl)-1,3,4-oxadiazole-2(3H)-thione (CODMHQ), which was characterized by elemental analysis and spectral studies. The transition metal chelates viz. Cu2+, Ni2+ , Co2+ , Mn2+ and Zn2+ of the product were prepared and characterized by metal-ligand (M:L) ratio, IR and reflectance spectroscopies and magnetic properties. The antifungal activity of that synthesized compound and its metal chelates was screened against various fungi. The results show that all these samples are good antifungal agents.

References

  1. A. Husain, M. Ajmal, Acta Pharm., 2009,59,223.
  2. H.Kumar, S. A. Javed, S.A.Khan, M. Amir, European Journal of Medicinal Chemistry,2008,43,2688e2698.
  3. K.Manjunatha,B.Poojary,P.L.Lobo,J.Fernandes, N.S.Umari,European Journal of Medicinal Chemistry,2010,45,5225e5233.
  4. M.Akhter, A.Husain,B. Azad, M.Ajmal,European Journal of Medicinal Chemistry,2009,44,2372.
  5. B. Jayashankar, K. M. Lokanath Rai , N. Baskaran, H.S. Sathish,European Journal of Medicinal Chemistry, 2009,44,3898.
  6. T.Chandra, N.Garg, S.Lata, K.K.Saxena, A.Kumar, European Journal of Medicinal Chemistry,2010,45,1772.
  7. A.S. Aboraia, H.M. Abdel-Rahman,N. M. Mahfouz and M.A. EL-Gendy, Bioorganic & Medicinal Chemistry,2006,14,1236.
  8. L.Jin, J.Chen, B.Song, Z.Chen, S.Yang, Q.Li,D.Hu and R.Xu, Bioorganic & Medicinal Chemistry Letters,2006,16,5036.
  9. Q.Zheng, X.Zhang, Y.Xu,K.Cheng, Q.Jiao, H.Liang Zhu,Bioorganic & Medicinal Chemistry,2010,18,7836.
  10. K.A.Kumar, P.Jayaroopa,G.V.Kumar, International Journal of ChemTech Research,2012,4(4)4,1782.
  11. M.M.Raikhshtat,S.B.Savvin and L.A. Gribov,Zh Anal. Khim.,1979,34,1886.
  12. L.A.Gribov, S.B.Savvin and M.M.Raikhshtat,Zh. Anal. Khim.,1980,35,1469.
  13. K.A. Oster and M.J.Golden,J. Am. Phrm. Assoc. Sci. Ed., 1947,37,283.
  14. K.A. Oster and M.J.Golden,Exp. Med. Surg.,1949,37.
  15. J.P. Philips, Chem. Review,1984,56, 271.
  16. J.H. Barkhater and R.I.Teib, J.Org.Chem.,1968,26,4078.
  17. A.Kenichiro, T. Zaaea and T. Sakurasaaea, seni Gakkaiski,2001,57,229.
  18. T.D. Portanna, B.P.Anana, and Z.A.Rajvin,Visakamol soedin,1975,17,120.
  19. L.Katshutoshi and L.Hideki,Japan patent,1998,1017953.
  20. W.Abraham, K.Rami and P.Abrahaks,U.S.Patent,1976,4317887.
  21. A.D.Dunya, S.J.Sukhina, V.G.Sinyavskii and Y.P. Kabrak,Ukr. Khim zh., 1982, 48,1087.
  22. C. Xiamren,F.Yushi, L.Hisann, H.Kazuhisa and A.Kusabbura, Anal. Sci, 1955,11,313.
  23. Patel,D.K and Singh,A.,E-journal of chemistry,6(4),1017(2009).
  24. K. K. Oza, H. S. Patel, Bulgarian Chemical Communications,2010,42(2),103.
  25. P.Mishra, V. Jatav and S.K. Kashaw, J. India Chem. Soc., 2006,83,1165.
  26. A.I.Vogel,Textbook of Quantitative Chemical Analysis, ELBS 5th Edn. London, 1996.
  27. W.R. Baily and E.G. Scott, Diagnostic Microbiology, The C. V. Moshy Co. St. Lovis,1966, 257.
  28. B.R.Patil, Oriental J.Chem.,2006,18,547.
  29. Kaushik Joshi, Haresh Ram, Bhavesh Dodiya, Hardik Bhatt, Chemistry & Biology Interface, , 2022, 12, 1, 7-14.
  30. Kaushik Joshi, Hardik Bhatt and Nikunj Dave, Asian J. of Chemical Sciences, 2022 11(1): 10-16.
  31. K. A. Joshi, H. B. Bhatt and K. M. Kapadiya, Current Chemistry Letters, 2021, (10) 479–488.
  32. K. A. Joshi, H.P.Pandya, journal of advance scientific research 2020,11(4), 55-60.
  33. Kaushik A. Joshi, Chauhan V., Journal of advance scientific research , 2020, 11(1), 44-49.
  34. K. A. Joshi, N R Makwana, International journal for innovative research in multidisciplinary field, 2019.Issue 7, 16-21.
  35. Kaushik A. Joshi, Haresh K. Ram, International Journal of Applied Chemistry,   201713(1),135-140.
  36. Arun Vaghasiya, Kaushik Joshi, Jatin Upadhiyay, IJRAR, 2021, 8 (2), 706-711.

International Journal of Scientific Research in Science and Technology

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Published

2018-10-30

Issue

Volume 4, Issue 10, September-October-2018

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Research Articles

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How to Cite

[1]
RajeshKumar A. Chauhan, Kaushik A. Joshi, Ninad Bhatt, Dr. G. D. Acharya, " Synthesis and Antifungal Studies of New Metal Complexes of 1, 3, 4-Oxadiazole derivatives (CODMHQ), International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 4, Issue 10, pp.560-567, September-October-2018.