A Review Scale Up Fermentation Procedure

Authors

  • Sikander Ali  Institute of Industrial Biotechnology, Government College University, Lahore, Pakistan
  • Muhammad Faiq Ali  Institute of Industrial Biotechnology, Government College University, Lahore, Pakistan
  • Maryam Sameer  Institute of Industrial Biotechnology, Government College University, Lahore, Pakistan
  • Zahra Rafique  Institute of Industrial Biotechnology, Government College University, Lahore, Pakistan

Keywords:

Fermentation, Scale Up, Pilot Plant Scale, Scale Down

Abstract

Due to the larger size and scale of industrial fermentation setups it is vital to succeed beforehand studies of possible complications, due to increase in scale, and to sort out ways to tackle them. Scale up studies are executed at the laboratory or pilot plant scale to generate data that can be used to anticipate and construct the large scale industrial fermenters with ample confidence that it would function according to all its expected behaviors. Hence, scale up studies not only help understanding the technical components of a large-scale fermentation setup but also reduce the economic risk involved in the case of direct investment on large scale production.

References

  1. Agrawal,A.K. and P. Parihar. 2009. Industrial Microbiology: Fundamentals and Applications. AbeBooks Seller,India.
  2. Bylund,F.,E. Collet,S.O. Enfors and G. Larsson. 1998. Substrate gradient formation in the large-scale bioreactor lowers cell yield and increases by-product formation. Biopro. Eng.,18:171-180.
  3. Calam,C.T. 1976. Starting investigational and production cultures. Pro. biochem.,11(3): 7-12.
  4. Chung,H.J.,W. Bang and M.A. Drake. 2006. Stress response of Escherichia coli,Comp. Review. Food Sci. Food Safe.,5: 52-64.
  5. Fox,R.I. 1978. The applicability of published scale up criteria to commercial fermentation processes. Pros.1st Eur.con.biotechnol.,1:80-83.
  6. Garcia-Ochoa,F. and E. Gomez. 2009. Bioreactor scale-up and oxygen transfer rate in microbial processes: an overview. Biotechnology advances.,27(2): 153-176.
  7. Jem,K. J. 1989.Scale down techniques in fermentation,Biopharma. 2: 30-39.
  8. Johnner P. S.,H. W. Lee1,Y. C. Kim and M. W. Chang. 2013. A: Scaling-up Synthesis from Laboratory Scale to Pilot Scale and to near Commercial Scale for Paste-Glue Production. J. of Eng. and Tech. Sci.,45(1): 9-24.
  9. Lara,A.R.,E. Galindo,O.T. Ramirezand and L.A. Palomares. 2006. Living with heterogeneities in bioreactors: understanding the effects of environmental gradients on cells. Mol. Biotechnol.,34(3): 355-381.
  10. Larsson,G.,M. Tornkvist, E. S. Wernersson,C. Tragardh,H. Noorman and S.O. Enfors. 1996. Substrate gradients in bioreactors: Origin and consequences,Biopro. Eng.,14(6): 281-289.
  11. Lillly,M.D. 1983. Problems in process scale up,In: Nisbet,I.J. and D.J. Wintanley (Ed.),Bioactive microbial products 2,Development and products. Academic process,London,pp. 79-90.
  12. Lin,H.Y. and Neubauer,P. 2000. Influence of controlled glucose oscillations on a fed-batch process of recombinant Escherichia coli. J. Biotechnol.,79(1): 27-37.
  13. Michael J. W.,N. L. Morgan,J. S. Rockey,G. Higton. 2002. Industrial Microbiology: An Introduction. Blackwell Science,Oxford,UK.
  14. Orgorzaly,H.J. 1958. The use of pilot plants in scale up. In: R. Fleming,(Ed.),Scale up Practice.
  15. Palluzi,R.P.,1992. Pilot Plant Design,Construction and Operations. Mcgraw-Hill pulishers.
  16. Ramasubramaniyan P.,C. S. Raj,O. Nagarajan,D. Sherly,L. Subramanian and P. Solairaj. 2014. Pilot Scale-up Techniques for Solid Dosage Form – An Overview for Tablets. World Journal of Pharmaceutical Research.,3(8): 925-931.
  17. Rios,M. 2012. Anniversary Upstream. BioProcess International.,10(6): 10-13.
  18. Schmidt,F. R. 2005. Optimization and scale up of industrial fermentation processes. App. Micro. biotech.,68(4): 425-435.
  19. Schweder,T.,E. Kruger,B. Xu,B. Jurgen,G. Blomsten,S.O. Enfor and M. Hecker. 1999. Monitoring of genes that respond to process-related stress in large-scale bioprocesses. Biotech. Bioeng.,65(2): 151-159.
  20. Srivasta,M. L. 2008. Fermentation Technology. Alpha Science publisher,pp.100-5.
  21. Stanbury,P.,A. Whitaker and S. Hall. 2016. Principle of fermentation technology. (3rd Ed) Butterworth-Heinemann publishers,pp. 269-72.
  22. Xu,B.,M. Jahic,G. Blomsten and S.O. Enfors. 1999. Glucose overflow metabolism and mixed-acid fermentation in aerobic large-scale fed-batch processes with Escherichia coli. App. Microbio. and Biotech.,51(5): 564-571.

International Journal of Scientific Research in Science and Technology

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Published

2018-04-30

Issue

Volume 4, Issue 5, March-April-2018

Section

Research Articles

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How to Cite

[1]
Sikander Ali, Muhammad Faiq Ali, Maryam Sameer, Zahra Rafique, " A Review Scale Up Fermentation Procedure , International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 4, Issue 5, pp.1301-1307, March-April-2018.