Enzymatic Functionalization Of Polyisobutylenes(Pib) Polymers
Keywords:
Polyisobutylenes(PIB), hydrophobicity, hemocompatibility, copolymerization, methacrylate-telechelic, 2-hydroxyethyl methacrylate, biocompatilibityAbstract
The aim of this research was to enzymatically functionalize Polyisobutylenes(PIB). The unique combination of properties including chemical/oxidative resistance, low Tg, hydrophobicity, biostability and biocompatibility renders polyisobutylene (PIB) an ideally suitable polymer for biomedical applications.(1,2) PIB-based amphiphilic networks, which are prepared by copolymerization of hydrophilic monomers including 2-hydroxyethyl methacrylate, N,N-dimethyl acrylamide, sulfoethyl methacrylate and 2-(dimethylamino)ethyl methacrylate with hydrophobic methacrylate-telechelic .PIB crosslinkers, have shown interesting properties for biomedical applications such as biocompatilibity, biostability, hemocompatibility, control of swelling by change in composition, controlled release of drugs and pH-sensitive swelling.
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