Optimization of Nanoparticle Formulation of Neostigmine Bromide

Abstract

In the recent days targeted drug delivery has gained more prominence for various advantages like site specific delivery and controlled release from the formulations. Amongst the plethora of avenues explored for targeted drug delivery, polymeric nanoparticles backed foremost attention offering local drug delivery and controlled drug release solving problems like tissue damage and drug wastage. Formulating nanoparticles with polymers may provide a significant increase in the gastrointestinal residence time. Neostigmine bromide is a cholinesterase inhibitor used for the treatment of Myasthenia Gravis and is given by conventional routes like oral and intra venous. Polymeric nanoparticles of Neostigmine Bromide using synthetic and semi synthetic polymers like Chitosan and ethyl cellulose were prepared by emulsification solvent evaporation method. The nanoparticles were characterized for their preformulation and post formulation parameters like particle size determination, drug entrapment efficiency, particle percentage yield, in vitro drug release and stability studies.