Identification of Potential Lead Compounds Against Snake Neurotoxin in Rauvolfia Serpentina Through Molecular Docking

Authors

  • Y. N. Joshi  Department of Bioinformatics, Walchand Centre for Biotechnology, WCAS, Solapur, Maharashtra, India
  • Iravati Sodal  Department of Biotechnology, Walchand Centre for Biotechnology, WCAS, Solapur, Maharashtra, India
  • Tejaswini Kale  Department of Bioinformatics, Walchand Centre for Biotechnology, WCAS, Solapur, Maharashtra, India
  • Shraddha Patange  Department of Bioinformatics, Walchand Centre for Biotechnology, WCAS, Solapur, Maharashtra, India
  • Vinay Gote  Department of Biotechnology, Walchand Centre for Biotechnology, WCAS, Solapur, Maharashtra, India

Keywords:

Neurotoxins, Venom Protein, Rauvolfia Serpentina, Lead, Docking.

Abstract

In all over the world including India, snake bite is a serious health problem which possess singnificant amount of mortality as well as abnormality. In world Bangarus caeruleus (Indian krait), Naja naja (Indian cobra), Dendroaspis polylepispolylepis (Black mamba),Oxyuranus microlepidotus (Inland taipan) are most venomous snake species belonging from neurotoxin family. Primarily neurotoxins affect the nervous system by strongly binding with receptor such as nicotinic acetylcholine (nAchRs). In modern medicine, immunotherapy is only treatment for snake bite but it has many limitations which includes adverse side effects to the patient. Herbal medicine is another way for snake bite victims which causes less side effects than antivenom therapy. For the identification of lead compounds and to demonstrate the drug activity, In-silico technique is the best option. In current studies, with the help of In-silico tools, we identified various potential lead compounds from Rauvolfia serpentina against snake neurotoxins. In present investigation chemical molecules present in Rauvolfia serpentina were docked with each of four neurotoxin venom protein using HEX software. Most potential lead compounds found after docking are 2,6-dimethoxy benzoquinone and Thebaine.

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International Journal of Scientific Research in Science and Technology

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Published

2020-01-30

Issue

Volume 7, Issue 1, January-February-2020

Section

Research Articles

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How to Cite

[1]
Y. N. Joshi, Iravati Sodal, Tejaswini Kale, Shraddha Patange, Vinay Gote "Identification of Potential Lead Compounds Against Snake Neurotoxin in Rauvolfia Serpentina Through Molecular Docking" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 7, Issue 1, pp.180-186, January-February-2020.