Design, Synthesis and Characterization of Some Novel benzamide derivatives and it's Pharmacological Screening

Authors

  • Akshay R. Yadav  Department of Pharmaceutical Chemistry, Rajarambapu college of Pharmacy, Kasegaon, Maharashtra, India
  • Shrinivas K. Mohite  Department of Pharmaceutical Chemistry, Rajarambapu college of Pharmacy, Kasegaon, Maharashtra, India

DOI:

https://doi.org/10.32628/IJSRST20723

Keywords:

Benzamide, Microwave, Anti-Inflammatory Activity

Abstract

The new series of substituted N-(phenylcarbamothioyl)benzamide derivatives (2a-2f) was designed, development and synthesized by using conventional and microwave method. In present work 6 different N-(phenylcarbamothioyl)benzamide were synthesized. Substituted benzoyl chloride is converted into benzoyl isothiocyanate by esterification. Benzoyl isothiocyanate is converted into Substituted (phenylcarbamothioyl)benzamide by treating with different types of substituted aniline. Confirmation of the chemical structure of the synthesized was substantiated by TLC, IR, 1H NMR, MS spectroscopy.Novel synthesized compounds screened for their in vivo and in-vitro anti-inflammatory studies and compound 2f shows promising anti-inflammatory activity.

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International Journal of Scientific Research in Science and Technology

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Published

2020-04-30

Issue

Volume 7, Issue 2, March-April-2020

Section

Research Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Akshay R. Yadav, Shrinivas K. Mohite "Design, Synthesis and Characterization of Some Novel benzamide derivatives and it's Pharmacological Screening" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 7, Issue 2, pp.68-74, March-April-2020. Available at doi : https://doi.org/10.32628/IJSRST20723