Spectrophotometric Determination of Apixaban in Bulk Drug and Oral Dosage Formulation

Authors

  • Deepshikha Sharma  Department of Chemistry, Sheth L.H. Science College, (Scholars of Gujarat University, Ahmedabad) Mansa, India
  • Vikramsinh R. Chauhan  Department of Chemistry, Sheth L.H. Science College, Mansa, Gujarat University, Ahmedabad, India.
  • Kartik B. Vyas  Department of Chemistry, Sheth L.H. Science College, Mansa, Gujarat University, Ahmedabad, India.

DOI:

https://doi.org//10.32628/IJSRST207263

Keywords:

Apixaban, Spectrophotometric, UV-Vis, Atrial fibrillation, DOAC

Abstract

A simple, rapid, cost effective and extractive UV-Vis spectrophotometric method has been developed for the determination of Apixaban (AP) in bulk drug and pharmaceutical formulation. It was based on UV-Vis spectrophotometric measurements in which the drug reacts chromogenic reagent (N-(1-napthyl) ethylene diamine dihydrochloride solution) in acidic medium and give stable pale yellow colored complex which exhibits absorption maximum at 680 nm. Beer’s law was obeyed in the concentration range of 5 - 50 μg /ml. This method was tested and validated for various parameters according to ICH guidelines. The proposed method was successfully applied for the determination of AP in oral formulation. The results demonstrated that the procedure is accurate, precise and reproducible (relative standard deviation < 2 %). As it is simple, cheap and less time consuming, it can be suitably applied for the estimation of LA in dosage forms in quality control labs.

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International Journal of Scientific Research in Science and Technology

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Published

2019-05-20

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Volume 6, Issue 3, May-June-2019

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Research Articles

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How to Cite

[1]
Deepshikha Sharma, Vikramsinh R. Chauhan, Kartik B. Vyas, " Spectrophotometric Determination of Apixaban in Bulk Drug and Oral Dosage Formulation, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 6, Issue 3, pp.377-385, May-June-2019. Available at doi : https://doi.org/10.32628/IJSRST207263