Suitable Polymers in Floating Gastro-Retentive Drug Delivery

Authors

  • Kaustubh Gavali  Department of Pharmaceutics, Appasaheb Birnale College of pharmacy, Sangli, Maharashtra, India
  • Preeti Karade  

DOI:

https://doi.org//10.32628/IJSRST207269

Keywords:

Keywords: Gastro retentive, Floating, Polymers.

Abstract

Gastro-retentive drug delivery is novel drug delivery system which is emerged for controlled and targeted delivery of drug especially when target site lies in or near the stomach. The drug with absorption window in stomach, locally acting drug in stomach, etc. are the best suitable candidate for this drug delivery system. It can be formulated in various types like floating, expandable & unfoldable, Raft forming, swelling system Bio adhesive, High density system etc. The gastro-retentive form can be used in various dosage forms like tablet, capsule, microsphere, granules, powders, pills and laminated films according to the need. It can be also formulated as single unit and multiple unit dosage form but sometime this gastro-retention is unpredictable due to effect of pH, gastric mobility, effect of food etc. This review mainly focuses on the floating drug delivery its types, polymer used in floating drug delivery and application.

References

  1. Swarbrick J. Encyclopaedia of Pharmaceutical Technology. Third edition, Volume 2; InformaHealthcare, New York, 2007.
  2. Kawashima Y, Takeuchi H, Yamamoto H. Handbook of Pharmaceutical Controlled Release Technology. MarcellDekker Inc, New York, 2000.
  3. Brahma N. Singh, Kwon H. Kim., Floating drug delivery systems - an approach to oral controlled drug delivery via gastric retention, Journal of Controlled Release, 2000; 63 (3): 235-259.
  4. Kengar Manohar D, Howal Rohit S., Aundhakar Dattatray B., Nikam Amit V., Hasabe Priyajit S., Physico-chemical Propertiesof Solid Drugs: A Review, Asian Journal of Pharmacy and Technology2019: 9(1): 53-59.
  5. SushilShah. Floating drug delivery systems: Rationale for drug selection. Journal of Pharmaceutical Care Health Systems 2015; 2 (4). 8.
  6. Vinod KR, Gangadhar M, Sandhya S, David Banji. Critical assessment pertaining to gastric floating drug delivery systems. Hygeia Journal for drugs and medicines 2013; 5(1): 41-58.
  7. Nayak A K., Maji R, Das B. Gastroretentive drug delivery systems: a review. Asian J Pharm Clinical Research 2010; 3 (1), 2-10.
  8. Gurangpatel Ajay Tiwari. Floating microspheres as a noval root for H2 blocker. Nirav Rabadia Jaipur National University, Jagatpur, Jaipur(Rajastan) India. IJRP, 3(2): 45-52.
  9. Talukder R, Fissihi R. Drug Development and Ind Pharm, 2004; 30(10): 1019-1028.
  10. Sangekar, S., Evaluation of effect of food and specific gravity of the tablets on gastric retention time. Int.J.Pharm, 1985; 35:34-53.
  11. Nayak AK, Maji R, Das B. Gastroretentive Drug Delivery systems: a review. Asian Journal of Pharmaceutical and Clinical Research. 2010;3(1):2-10.
  12. Whitehead L, Fell JT and Collett JH. Development of a gastroretentive dosage form.Eur J Pharm Sci. 1996;4:182.
  13. Hoffman A, Stepensky D, Lavy E, Eyal S, Klausner E, Friedman M, Pharmacokinetic and pharmacodynamics aspects of gastroretentive dosage forms. Int J Pharm 2004;277:141 -153.
  14. Garg S, Sharma S. Gastroretentive drug delivery systems. Business Briefing: Pharmatech 2003: 160-66.
  15. Alzaher W, Shaw J, Al-kassas. GastroretentiveFormulations for Improving Oral Bioavailability of Drugs-Focus on Microspheres and their Production. Current Drug Delivery.2016; 13(5):646-651.
  16. Shakyaa R, Thapaa P, Sahab RN. In vitro and in vivo evaluation of gastroretentive floating drug delivery system of ofloxacin Asian J Pharm Sci. 2013;8(3):191-8.
  17. Baumgartner S, Kristl J, Vrecer F, Vodopivec P, Zorko B. Optimisation of floating matrix tablets and evaluation of their gastric residence time. Int J Pharm. 2000;195(1-2):125-35.
  18. Yang L, Fassihi R. Zero order release kinetics from self correcting floatable configuration drug delivery system. J Pharm Sci.1996; 85:170-173.
  19. Burns SJ, Attwood D, Barnwell SG. Assement of a dissolution vessel designed for use with floating and erodible dosage forms. Int J Pharm. 1998; 160:213-218.
  20. Joseph NJ, Laxmi S, Jayakrishnan A. A floating type oral dosage form for piroxicam based on hollow microspheres: in vitro and in vivo evaluation in rabbits. J Control Release.2002; 79: 71-79.
  21. Soppimath KS, Kulkarni AR, Rudzinski WE, Aminabhavi TM. Microspheres as floating drug delivery system to increase the gastric residence of drug. Drug Metab Rev. 2001; 33:149-160.
  22. Chowdary, K. P. R., KoteswaraRao, N., &Malathi, K. (2004). Ethyl cellulose microspheres of glipizide: Characterization, in vitro and in vivo evaluation. Indian Journal of Pharmaceutical Sciences, 66(4), 412-416.
  23. Fischer, S., Foerg, C., Merkle, H. P., & Gander, B. (2004). Chitosan coated PLGA microspheres—A modular system for targeted drug delivery. Eur Cell Mater, 7, 11-12.
  24. Singh, A. kumar. role of natural polymers used in floating drug delivery system floating drug delivery system. J. Pharm. Sci. Innov, June, 2012; 1: 11–15.
  25. Kumar, G. natural polymers in the development of floating drug delivery systems: a review. Int. J. Pharm. Life Sci., 2013; 2(4): 165–178.
  26. Patra CN, Priya R, Swain S, Kumar Jena G, Panigrahi KC, Ghose D, Pharmaceutical significance of Eudragit: A review, Future Journal of Pharmaceutical sciences, 2017. doi: 10.1016/j.fjps.2017.02.001
  27. Hegyesi, d. study of the widely used ethylcellulose polymer as film forming and matrix former ph. d. Thesis DiánaHegyesi Pharmacist, 2016.
  28. Rowe Raymond, Paul Sheskey. Pharmaceutical press.Handbook of Pharmaceutical Excipient Sixth Edition, 2009.
  29. Fell J T, Whitehead L, Collet H, Prolonged gastric retention using floating dosage forms, Pharm Technol. 2000; 24(3):82-90.
  30. Moursy NM, Afifi NH, Ghorab DM, El-Saharty Y. Formulation and evaluation of sustained release floating capsules of Nicardipinehydrochloride. Pharmazie.2003; 58:38-43.
  31. Koli Vikranti W., Kengar Manohar D., Kamble Amruta B., Kumbhar Suraj B., Jadhav Rahul P., Binders Need and used in Solid Formulation, Asian J. Pharm. Tech. 2019; 9(2):129-134.

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Published

2020-04-30

Issue

Section

Research Articles

How to Cite

[1]
Kaustubh Gavali, Preeti Karade, " Suitable Polymers in Floating Gastro-Retentive Drug Delivery, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 7, Issue 2, pp.371-382, March-April-2020. Available at doi : https://doi.org/10.32628/IJSRST207269