Synthesis, Anticancer and Molecular Docking Studies of N-(1H-benzimidazol-2-yl-carbamothioyl)benzamide Analogues

Authors

  • Priyanka P. Rode  Department of Pharmaceutical Chemistry, Rajarambapu college of Pharmacy, Kasegaon, Maharashtra, India
  • Akshay R. Yadav  Department of Pharmaceutical Chemistry, Rajarambapu college of Pharmacy, Kasegaon, Maharashtra, India
  • Ankita V. Chitruk  Department of Pharmaceutical Chemistry, Rajarambapu college of Pharmacy, Kasegaon, Maharashtra, India
  • Dr. Shrinivas K. Mohite  Department of Pharmaceutical Chemistry, Rajarambapu college of Pharmacy, Kasegaon, Maharashtra, India
  • Dr. Chandrakant S. Magdum  Department of Pharmaceutical Chemistry, Rajarambapu college of Pharmacy, Kasegaon, Maharashtra, India

DOI:

https://doi.org/10.32628/IJSRST207463

Keywords:

MTT assay, VLife MDS 4.3 software, Molecular docking

Abstract

A series of novel N-(1H-benzimidazole-2-yl-carbamothioyl)benzamide derivatives were synthesized under microwave irradiation and evaluated for anticancer activity. The synthesized compounds were characterized by IR, 1H-NMR, and mass spectral data. Complexity associated with cancer disease and prevalence of diversified cell populations vindicates highly specific treatment options for treatment of cancer. Resistance to these anticancer agents has posed a great hindrance in successful treatment of cancer. Pondering this ongoing situation, it was speculated to develop novel compounds targeting cancer. All the newly synthesized compounds 3a-f were further evaluated for anticancer activity against MCF-7 cell lines using MTT assay. Molecular docking studies were performed using VLife MDS 4.3 software. The compounds 3c exhibited good docking scores of -60.37. The anticancer and docking results highlight the fact that the synthesized compounds 3c could be considered as possible hit as therapeutic agents. A significant correlation was observed between the in silico and the in vitro studies.

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International Journal of Scientific Research in Science and Technology

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Published

2020-08-30

Issue

Volume 7, Issue 4, July-August-2020

Section

Research Articles

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How to Cite

[1]
Priyanka P. Rode, Akshay R. Yadav, Ankita V. Chitruk, Dr. Shrinivas K. Mohite, Dr. Chandrakant S. Magdum "Synthesis, Anticancer and Molecular Docking Studies of N-(1H-benzimidazol-2-yl-carbamothioyl)benzamide Analogues " International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 7, Issue 4, pp.204-212, July-August-2020. Available at doi : https://doi.org/10.32628/IJSRST207463