Synthesis, Characterization and Biological Activate 5-(Hydroxymethyl) Pyrrolidin-2-One at Room Temperature

Authors

  • Veerappan Jeyachandran  Department of Chemistry, Bharath Institute of Higher Education and Research, Selaiyur, Chennai, Tamil Nadu, India

DOI:

https://doi.org//10.32628/IJSRST207668

Keywords:

Pyroglutamic Acid, Anti-Inflammatory, Doxapram And Alzheimer's Seizures

Abstract

A new class of chiral pyrrolidinone was synthesized from (5S)-5-[(trityloxy)methyl] pyrrolidin-2-one (6) (Schemes 1 and 2). The synthetic design followed led to the insertion of various substituents at 1 and 5 of the pyrrolidinone moiety. Some of them possess two or three stereo centers, here configuration was retained under the mild condition. The new compounds also carry an imidazole moiety, which, along with the 2-pyrrolidinone template, may prove pivotal to several biological processes. The chiral pyrrolidinone (R) ring is incorporatedin various compounds with biological and pharmaceutical activities [1]. some of them are well known medicines, e.g., doxapram for patients with respiratory failure,piracetam for patients with Alzheimer’s seizures, and senile dementia, concussion and other neurological problems [2,3]. The properties and applications of pyroglutamic acid as a versatile building block in asymmetric synthesis has extensively been reviewed in the literature[4,5]. Some of them exhibited anti-inflammatory and antihypertensive activity [6,7]

References

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International Journal of Scientific Research in Science and Technology

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Published

2021-01-30

Issue

Volume 8, Issue 1, January-February-2021

Section

Research Articles

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How to Cite

[1]
Veerappan Jeyachandran "Synthesis, Characterization and Biological Activate 5-(Hydroxymethyl) Pyrrolidin-2-One at Room Temperature" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 8, Issue 1, pp.10-15, January-February-2021. Available at doi : https://doi.org/10.32628/IJSRST207668