Synthesis, Characterization of Novel Benzothiophene
DOI:
https://doi.org/10.32628/IJSRST207669Keywords:
Ant-Iinflammatory, Thiophenone, Sertaconazole And AsthmaAbstract
A library of novel benzo[b] thiophenehave been synthesized regioselectively in good yields through the one-pot domino reactions of thiophenone, malononitrile and aromatic aldehydes in the presence of NaOEt. This transformation presumably involves Knoevenagel condensation
References
- Marketed as Evista® (Raloxifene Hydrochloride 60 mg). Grese, T.A.; Dodge, J. A.; Curr. Pharm. Des.,1998, 4, 71.
- Carter, G. W.; Young, P. R.; Albert, D. H.; Bouska, J.;Dyer, R.; Bell, R. L.; Summers, J. B.; Brooks, D. W.J. Pharmacol. Exp. Ther.,1991, 256, 929.
- Palkowitz, A.D.; Glasebrook, A. L.; Thrasher, K. J.; Hauser, K. L.; Short, L. L.; Phillips, D. L.; Muehl, B. S.; Sato, M.; Shetler, P. K.; Cullinan, G. J.; Pell, T. R.; Bryant, H. U. J. Med. Chem.,1997, 40, 1407; (b) Magarian, R. A.; Overacre, L. B.; Singh, S.; Meyer, K. L. Curr.Med. Chem.,1994, 1, 61.
- Thesen, R. Pharm. Ztg.,1995, 140, 44.
- Bleavins, M. R.; Igelsia, F. A.; McCay, J. A.; White, L.;Kimber, L.; Munson, A. E. Toxicology, 1995, 98, 111.
- Zhang, S.X.; Bastow, K. F.; Tachibana, Y.; Kuo, S.C.; Hamel, E.; Mauger, A.; Narayanan, V. L.; Lee, K.H. J. Med. Chem.,1999, 42, 4081.
- Shedid, S. A. M.; Hassan, H. M.; Kora, F. A.; El-Eisawy, R. M. J. Chem. Pharm. Res.,2011, 3, 388; (b) Isloor, A. M.; Kalluraya, B.; Sridhar, P. K. Eur. J. Med. Chem.,2010, 45, 825; (c) Radwan, M. A. A; Shehab, M. A.; El-Shenawy, S. M. Monatsh Chem.,2009, 140, 445
- Ono, S.; Yamafuji, T.; Chaki, H.; Todo, Y.; Maekawa, M.; Kitamura, K.; Kimura, T.; Nakada, Y.; Mozumi, K.; Narita, H. Biol. Pharm. Bull.,1995, 18, 1779–1783.
- Sato, M.; Turner, C. H.; Wang, T.; Adrian, M. D.; Rowley, E.; Bryant, H. U. J. Pharmacol. Exp. Ther.,1998, 287, 1–7.
- Sorbera, L. A.; Leeson, P.; Castaner, J. Drugs Fut.,1999, 24, 740.
- Wright, C. D; Stewart, S. F.;Kuipers, P. J.;Hoffman, M. D.;Devall, L. J.;Kennedy, J. A.;Ferin, M. A.;Thueson, D. O.;Conroy, M. C. J. Leukoc. Biol.,1994, 55, 443–451.
- Towle, M. J.;Lee, A.;Maduakor, E. C.;Schwartz, C. E.;Bridges, A. J.;Littlefield, B. A. Cancer Res.,1993, 53, 2553–2559.
- Carballo, M.;Conde, M.;Tejedo, J.;Gualberto, A.;Jimenez, J.;Monteseirín, J.;Santa María, C.;Bedoya, F. J.;Hunt, S. W. 3rd.;Pintado, E.;Baldwin, A. S. Jr.;Sobrino, Fr. Mol. Genet. Metab.,2002, 75, 360–368.
Downloads
Published
2021-01-30
Issue
Section
Research Articles
License
Copyright (c) IJSRST

This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
[1]
Veerappan Jeyachandranan "Synthesis, Characterization of Novel Benzothiophene" International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 8, Issue 1, pp.38-41, January-February-2021. Available at doi : https://doi.org/10.32628/IJSRST207669