Michael Addition of 2, 4 Thiazolindione on Chalcone Mediated by Lipase in Nonaqueous Solvent
DOI:
https://doi.org/10.32628/IJSRST207670Keywords:
Chalcone, Thiazolindione, Michael Addition, Organic SolventAbstract
Biocatalysts are highly enantioselctive catalysts that enforce reactive conformations of nature substrate. We report here a novel type of Michael additions on chalcone catalysed by lipase in nonaqueos solvent in efficient conditions. We first time report 2, 4 thiazolindione as Michael donor for Michael additions on chalcone, isolated product with excellent yield.
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