Development and Validation of Absorption Correction UV-Spectrophotometry Method for Simultaneous Estimation of Ranitidine HCL and Dicyclomine Hydrochloride in Their Marketed Formulation

Authors

  • Bhumi Kantariya  Lecturer Department of Pharmaceutical Chemistry, Indian Institute of Ayurvedic Pharmaceutical Sciences, Gujarat Ayurved University, Jamnagar, Gujarat, India
  • Dr Greeva Bhatt  Lecturer Department of Pharmaceutical Chemistry, Indian Institute of Ayurvedic Pharmaceutical Sciences, Gujarat Ayurved University, Jamnagar, Gujarat, India
  • Dr. Mehul Mehta  Lecturer Department of Pharmaceutical Chemistry, Indian Institute of Ayurvedic Pharmaceutical Sciences, Gujarat Ayurved University, Jamnagar, Gujarat, India
  • Urmi Kanatria  Lecturer Department of Pharmaceutical Chemistry, Indian Institute of Ayurvedic Pharmaceutical Sciences, Gujarat Ayurved University, Jamnagar, Gujarat, India
  • Ravi Dalsaniya  Lecturer Department of Pharmaceutical Chemistry, Indian Institute of Ayurvedic Pharmaceutical Sciences, Gujarat Ayurved University, Jamnagar, Gujarat, India

DOI:

https://doi.org//10.32628/IJSRST218140

Keywords:

UV Spectrophotometric absorption correction method; Ranitidine Hydrochloride (RANTD); Dicyclomine Hydrochloride (DICY); ICH guidelines; Validation.

Abstract

A Simple, selective, precise and rapid absorption correction Spectrophotometric method has been developed and validated as per ICH guideline for the simultaneous estimation of Ranitidine Hydrochloride and Dicyclomine Hydrochloride in tablet dosage form. Method is base on UV Spectrophotometric for determination of two drug, by using Methanol as a solvent and diluted the same with 0.1N NaOH, solution. In this UV method, the two wavelength were selected, 311.4 nm and at 217 nm for RANTD and DICY, respectively. this method was validated according to ICH guideline and Linearity range, was found to be 7.5-37.5

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International Journal of Scientific Research in Science and Technology

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Published

2019-03-30

Issue

Volume 6, Issue 2, March-April-2019

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Research Articles

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[1]
Bhumi Kantariya, Dr Greeva Bhatt, Dr. Mehul Mehta, Urmi Kanatria, Ravi Dalsaniya, " Development and Validation of Absorption Correction UV-Spectrophotometry Method for Simultaneous Estimation of Ranitidine HCL and Dicyclomine Hydrochloride in Their Marketed Formulation, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 6, Issue 2, pp.851-863, March-April-2019. Available at doi : https://doi.org/10.32628/IJSRST218140