Synthesis, Characterization and Antimicrobial Activity of pyrimidothionyl - [Triazolo-thiadiazole] Fused Heterocycles

Authors

  • Pranay Shah  Sheth M. N. Patel Science College, Patan, Gujarat, India
  • R. I. Patel  Sheth M. N. Patel Science College, Patan, Gujarat, India
  • P. J. Vyas  Sheth M. N. Patel Science College, Patan, Gujarat, India

Keywords:

Pyrimidinthione, Triazole-Thiadiazole, Spectral Study, Antibacterial And Antifungal Activities.

Abstract

The reaction of 6-methyl-2-thioxo-4-phenyl-1,2,3,4-tetrahydropyrimidone carbo hydrazides (1) with CS2 in presence of KOH yielded 5-(4-amino-3-mercapto-4,5-dihydro-1H-1,2,4-triazol-5-yl)-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-thione (2). The compound (2) on reaction with various aromatic acids afforded 5-[6-aryl-2,3-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]-6-methyl-4-phenyl-3,4-dihydro pyrimidin-2(1H)-thiones (3a-e). The structures of fused heterocycles compounds were confirmed by elemental contents and spectral features. The antimicrobial activities of all compounds have also been monitored against plant pathogens.

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International Journal of Scientific Research in Science and Technology

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Published

2029-01-30

Issue

Volume 6, Issue 1, January-February-2019

Section

Research Articles

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How to Cite

[1]
Pranay Shah, R. I. Patel, P. J. Vyas, " Synthesis, Characterization and Antimicrobial Activity of pyrimidothionyl - [Triazolo-thiadiazole] Fused Heterocycles, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 6, Issue 1, pp.603-608, January-February-2019.