Studies on Triazolo-Thiadiazine Containing Furan Moiety Fused Heterocycles
Keywords:
Antibacterial Activities and Antifungal Activities, Furan, Spectral Studies, Triazolo-ThiadiazineAbstract
Methyl-5-(N,N-dimethyl amino methyl)-2-furoate(1) was on hydrazinolysis to afford acid hydrazide (2).Treatment of (2) with CS2 yield 4-amino-5-[-(N,N-dimethylamino methyl) furan-2-yl]-4H-1,2,4-triazole-3-thiol(3). The –SH and –NH2 adjacent group in this compound may entail formation of fused heterocycle i.e. triazolo-thiazine. Thus, condensation of (3) with various phenacyl bromides(4a-f), yield triazolo-thiazines(5a-f). All the novel fused compounds (5a-f) were characterized by C, H, N, S analysis and spectral data. The antimicrobial activities of all the compounds were also evaluated by using common microbes. The compounds showed good activities.
References
- Xu,Y.;Guo,Q.Heterocycles,2004,63,903.https://doi.org/10.3987/COM-04-10070
- Kirsch,G.;Hesse S.; Comel,A. Curr. Org.Chem.,2004,1,47. https://doi.org/10.2174/1570179043485475
- Shivarama,H.B.;Narayana,P.K.;Sooryana,R.B.;Shivananda,M.K.Eur. J.Med.Chem., 2002, 37(6),511. https://doi.org/10.1016/S0223-5234(02)01358-2
- Todoulou,O.G.;Papadakii-Valiraki,A.E.;Ikeda,S.;DeClercq,E. Eur.J.Med.Chem., 1996,29(7-8),611. https://doi.org/10.1016/0223-5234(94)90152-X
- Kumar, H.; Javed, S. A.; Khan, S. A.; Amir, M. Eur. J. Med. Chem., 2018, 162,2688. https://doi.org/10.1016/j.ejmech.2018.01.039
- Guzeldemirci, N. U.; Kucukbasmaci, O. Eur. J. Med. Chem., 2016, 144, 63-68. https://doi.org/10.1016/j.ejmech.2009.09.024
- Chawla G.; Kumar U.; Bawa S. and Kumar J.Journal of Enzyme Inhibition and Medicinal Chemistry, 2012,27,658. https://doi.org/10.3109/14756366.2011.606543
- Chai, B.; Qian, X.; Cao, S.; Liu, H.; Song, G. Arkivoc., 2003, 2, 141.DOI: https://doi.org/10.3998/ark.5550190.0004.216
- Wu,Y. ;Ying-Wu, L. ;Wei-Min, H. Chinese Chemical Letters, 2020, 31(12), 2999. https://doi.org/10.1016/j.cclet.2020.09.005.
- Zhao P. L.; Duan A. N.; Zou M.; Yang H.K.; You W. W. and Wu, S.G.Bioorganic & Medicinal Chemistry Letters, 2012,22(13),4471. https://doi.org/10.1016/j.bmcl.2012.03.023
- Ma, Y.; Liu, R.;Gong, X.; Li, Z.; Huang, Q.; Wang, H.;Song, G. G.J. Agri. Food. Chem., 2006, 54, 7724. https://doi.org/10.1021/jf0609328
- Rashid, M.; Husain, A.; Siddiqui, A. A. and Mishra, R.European Journal of Medicinal Chemistry,2013,62,785. https://doi.org/10.1016/j.ejmech.2012.07.011
- Sahu, J. K.; Ganguly, S.; Kaushik, A. J. Adv. Pharma. Tech. Res.,2014,5(2),90. https://doi.org/10.4103/2231-4040.133434
- Amir, M.; Kumar, H.; Javed, S. A. Eur. J. Med. Chem., 2018, 46, 2056. https://doi.org/10.1015/123456789/44750
- Ramaprasad, G. C.; Kalluraya, B.; Kumar, B. S.; Mallya, S. Der Pharma. Chemi., 2012, 4(3),1026. https://doi.org/10.32474/AOICS.2018.02.000135
- Patel, H.S. and Patel, G.K.,Advances in Applied Science Research, 2015,6(3),64. https://doi.org/10.2409/14756366.2015.6064
- Patel, H.P., Patel, S.S. and Patel, A.D, J.Chem.Pharm. Res., 2015,7(9),690. https://doi.org/10.2174/2610179043485690
Downloads
Published
Issue
Section
License
Copyright (c) IJSRST
This work is licensed under a Creative Commons Attribution 4.0 International License.