Studies on Triazolo-Thiadiazine Containing Furan Moiety Fused Heterocycles
Keywords:
Antibacterial Activities and Antifungal Activities, Furan, Spectral Studies, Triazolo-ThiadiazineAbstract
Methyl-5-(N,N-dimethyl amino methyl)-2-furoate(1) was on hydrazinolysis to afford acid hydrazide (2).Treatment of (2) with CS2 yield 4-amino-5-[-(N,N-dimethylamino methyl) furan-2-yl]-4H-1,2,4-triazole-3-thiol(3). The –SH and –NH2 adjacent group in this compound may entail formation of fused heterocycle i.e. triazolo-thiazine. Thus, condensation of (3) with various phenacyl bromides(4a-f), yield triazolo-thiazines(5a-f). All the novel fused compounds (5a-f) were characterized by C, H, N, S analysis and spectral data. The antimicrobial activities of all the compounds were also evaluated by using common microbes. The compounds showed good activities.
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