Synthesis, Characterization and Biological Evaluation of Some Novel Heterocycles Based on Chalcones Derived from 5-aryl-2-furaldehyde

Authors

  • Vishvajitsinh Raj  Sheth M. N. Patel Science College, Patan, Gujarat, India
  • R. I. Patel  Sheth M. N. Patel Science College, Patan, Gujarat, India
  • P. J. Vyas  Sheth M. N. Patel Science College, Patan, Gujarat, India

Keywords:

Claisen-Scimdth condensation, Chalcone, Isoxazole, pyrimidones, dihydro pyrazoles, Spectral studies and Antibacterial activity.

Abstract

Chalcones were prepared by condensation of acetophenone (1) with 5-aryl-2-furaldehyde (2a-e) (Claisen-Scimdth condensation). These chalcones were post heterocyclised by their reactions respectively with hydroxyl amine, urea and phenyl hydrazine. The so called obtained derivatives respectively isooxazoles (3a-e), pyrimidones (4a-e) and dihydro pyrazoles (5a-e) characterized by IR, NMR and LC-MS spectroscopies and elemental analyses. All the produced compounds were evaluated for their antimicrobial activities.

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International Journal of Scientific Research in Science and Technology

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Published

2019-03-30

Issue

Volume 6, Issue 2, March-April-2019

Section

Research Articles

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How to Cite

[1]
Vishvajitsinh Raj, R. I. Patel, P. J. Vyas, " Synthesis, Characterization and Biological Evaluation of Some Novel Heterocycles Based on Chalcones Derived from 5-aryl-2-furaldehyde , International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 6, Issue 2, pp.891-901, March-April-2019.