A Mini-Review : Microemulsion as the Novel Carrier for Topical Drug Delivery

Authors

  • Lakshyaveer Singh  Department of Pharmacy, MJP Rohilkhand University Bareilly, Uttar Pradesh, India
  • Saurabh Mishra  Department of Pharmacy, MJP Rohilkhand University Bareilly, Uttar Pradesh, India
  • Kaushal Kumar   Department of Pharmacy, MJP Rohilkhand University Bareilly, Uttar Pradesh, India

Keywords:

Microemulsion, Percutaneous, Phase diagram, Pseudo-ternary, Topical

Abstract

In the designing of topical formulations of highly lipophilic drugs the clinical efficacy is compromised by their low aqueous solubility resulting in poor drug penetration through skin. Among the different innovative approaches that have been suggested for enhancing the penetration of lipophilic drugs through topical administration, microemulsions have shown better results. The microemulsion is a promising vehicle due to powerful ability to deliver drug through skin and large solubilizing capacities of lipophilic, hydrophilic and amphiphilic drug candidates. A microemulsion one of the pharmaceutical interests for new drug delivery is normally composed of oil, water surfactant and cosurfactant. Microemulsion can be defined as a transparent and clear solution obtained by titrating a normal coarse emulsion with medium chain alcohols to the point of clarity.

References

  1. Pilar Bstamante and AHC Chun,Physical Pharmacy,4rth edition ,519.
  2. Eccleston, G.M. Encyclopidia of Pharmaceutical Technology, ED. Swarbric, I.Boylar, J.C.,Marcel Dekker: New York Vol. 9,(992), ,375-421.
  3. Jain N.K. Targreted and controlled delivery 281-297.
  4. Razdan R and Devrajan P.V, Microemulsion A Review,Indian Drugs 40(3),2003), 39-146.
  5. Herbert, A. L., Martin M.R., Pharmaceutical dosage forms: Dispersed system,II        
  6. Edition, Gilbert.S. Banker, Marcel Dekker New York, Vol.3, 20-25.
  7. Puranajoti P., Patil R.T., Seth P.D., Bommareddy G., Dondeti P., Egbaria K., Design and Development of topical Microemulsion for Poorly Water-Soluble antifungal Agents,The Journal of applied research in Clinical and Experimental Therapeutics 2,(1)(2002)
  8. Qizhi Zhang, Xinguo Jiang, Wenming Jiang, Wei Lu, Lina Su, Zhenqi Shi, Preperation of nimodipine-loaded microemulsion for intranasal delivery oand evaluation on the targeting efficiency to the brain. Int. J. Pharm.,275(2004)85-90.
  9. Trotta,M., Ugazio,E., Gasco,M.R., Pseudo ternary phase dsiagrams of lecithin-based microemulsions:influence of mono alkyl phosphates. J.Pharm. Pharmacol.,47(1995)451-454.
  10. Rhee,Y.-S., Choi,J.-G., Park,E.-S., Chi,S.-C., Transdermal delivery of ketoprofen using microemulsions. Int. J. Pharm.,228(2001)161-170.
  11. Shinoda,K., Araki,M., Sadaghiani,A., Khan,A., Lindman,B., Lecithin-based microemulsions:phase behaviour and microstructure. J.Phys. Chem., 95(1991)989-993.
  12. Trotta,M., Cavalli,R., Ugazio,E., Gasco,M.R., Phas behaviour of microemulsion systems containing lecithin and lysolecithin as surfactants. Int. J. Pharm.143 (1996) 67-73.
  13. Lagues,M., Electrical conductivity of microemulsions:a case of stirred percolation., J. Phys.Litt.,40(1979)L331-L333.
  14. Gasperlin,M., Spiclin,P.,  Caprylocaproyl macrogolglycerides based microemulsions:physicochemical and phase behaviour properties. Scientica Pharmaceutica, 69(2001)157-158.
  15. Ljiljana Djordjevie,Marija Primorac, MirjanaStupar, Danina Krajisnik, Characterisation of caprylocaproyl macrogolglycerides based microemulsion drug delivery vehicles for an amphiphillic drug. Int. J. Pharm.,271(2004)11-19.
  16. Gao, Z.G., Choi,H.G., Shin,H.J., Park,K.M., Lim,S.J.,Hwang,K.J., Kim,C.K., Physicochemical characterization  and evaluation of a microemulsion system for oral delivery of cyclosporinA. Int. J. Pharm.,161(1998)75-86.
  17. Kale,N.J., Allen,L.V., Studies on microemulsions using Brij 96 as surfactant glycerin ethylene glycol and propylene glycol as cosurfactants. Int J. Pharm.,57(1989)87-93
  18. Kim,C.K., Ryuu,S.A., Park,K.M.,Lim,S.L., Hwang,S.J., Preparation and physicochemical characterization of phase inverted w/o microemulsion containing cyclosporin A. Int.J. Pharm.,147(1996)131-134
  19. Shukla Anuj, Janich mathur , John Konstange, Krause Annetf, Kiselev, A. Mikacl, Nen bert, H.H. Reinhord Investigation of pharmaceutical oil/water microemulsion by small angle scattering. Pharm. Res. 19(2002) 831- 886.
  20. Li,L., Nandi,I., Kim,K.H., Development of an ethyl laurate-based microemulsion for rapid-onset intranasal delivery of diazepam. Int. J. Pharm.,237(2003)77-85.
  21. Malcolmson,C.M., Lawrence,J., A comparision of the incorporation of model steroids into non-ionic micellar and microemulsion systems. J. Pharm. Pharmacol.,45(1993)141-143.
  22. Warisnoicharoen,W., Lansley,A.B., Lawrence,M.J., Nonionic o/w microemulsions: the effect of oil type on phase behaviour . Int. J. Pharm., 198(2000)7-27. 
  23. Hwang,S.R., Lim,S.J., Park,J.S., Kim,C.K., Phospholipid-based  microemulsion formulation of all-trans-retinoic acid for parenteral administration. Int. J. Pharm., 276(2004)175-183.
  24. Charman,S.A., Charman,W.N., Rogge,M.C., Wilson,T.D., Dutko,F.I., Ponton, C.W., Self-emulsifying systems formulation and biological evaluation of an investigative lipophilic compound. Pharm. Res.,9(1992)87-94.
  25. Lee,J.M., Park,K.M., Lim,S.J., Lee,M.K., Kim,C.K., Microemulsion formulation of clonixic acid: solubility enhancement and pain  reduction. J. Pharm. Pharmacol.,54(2002)43-49.
  26. Moreno,M.A., Frutos,P., Ballesteros M.P., Lyophilized lecithin based o/w microemulsions as a new and low toxic delivery system for amphotericin B. Pharm. Res., 18(2001)344-351.
  27. Muller,R.H., Heinemann,S., Fat emulsion for parenteral nutrition : evaluation of microscopic and laser light scattering methods for the determination of physical stability. Clin.  Nutr. 11 (1992) 223-272.
  28. Park, K.M., Kim, C.K., Preperation and evaluation of flurbiprofen-loaded microemulsion for parentral delivery. Int. J. Pharm.,181(1999)173-179.
  29. Park,K.M., Lee,M.K., Hwang,K.J., Kim,C.K., Phospholipid-based microemulsions of flurbiprofen by spontaneous emulsification process. Int J. Pharm.,183(1999)145-154.
  30. Sintov,A.C., Shapiro,L., New microemulsion vehicle facilitates precutaneous penetration in vitro and cutaneous drug bioavailability in vivo. J. Control. Release, 95(2004)173-183.
  31. Osborne,D.W., Ward,A.J., O’Neill ,K.J., Microemulsions as topoical delivery vehicles :in vitro transdermal studies of a model hydrophilic drug. J. Pharm. Pharmacol., 43(1991)450-454.
  32. Dreher,F., Walde,P., Walther,P., Wehrli,P., Interaction of a lecithin microemulsion gel with human stratum corneum and its effect on transdermal transport, J. Control. Release,45(1997)131-140.
  33. Schmalfuss,U., Neubert,R., Wohlrab,W.,  Modification of drug penetration into human skin using microemulsions. J. Control. Release,46(1997)279-285.
  34. Vinod Singh et al, Microemulsions as a promising delivery system: A Review, Ind J Pharm Edu Res, Vol 45 Issue 4(2011),392-401.

Downloads

Published

2018-06-25

Issue

Section

Research Articles

How to Cite

[1]
Lakshyaveer Singh, Saurabh Mishra, Kaushal Kumar , " A Mini-Review : Microemulsion as the Novel Carrier for Topical Drug Delivery, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 4, Issue 8, pp.943-952, May-June-2018.