Ageing, Neurodegeneration and Parkinson's Disease

Abstract

For the human development aging is one of the important aspect among which on cellular processes and functions are predispose to neurodegeneration and synthetic changes in the body are involved in the pathogenesis of Parkinson’s. The accumulation of the cellular development and their function leads to the progression of Parkinson’s. The formation of ROS, generation of oxidative stress, disruptions in inflammatory pathways like COX, LOX, formation of lewy bodies, protein degradation, genetic mutations, mitochondrial depletion and several other pathways involved in the pathogenies. These may be due to age related decline in acetylcholine and dopamine levels. On medical findings from survey it's been discovered Parkinson’s is age associated ailment and quite a times irreversible yet curable on early stages and can be treated with dopamine and acetylcholine analogues, where levodopa and carbidopa is considered to be the drug of choice at different doses for the inhibiting progression of Parkinson’s.