Formulation, Development and Evaluation of Anti-Viral Microspheres Using Ionotopic Gelatin Method

Authors

  • Mr. Saurabh Jawahar Sanghavi  Research Scholar, Mansarovar Global University, Sehor, MP, India
  • Sharad Verma  Sharda University, Greater Noida, India
  • Adarsh Raj  Sharda University, Greater Noida, India
  • Gore Avinash Bharat  Maharashtra College of pharmacy Nilanga, India
  • Budhe Vaishnavi Jaykumar  Maharashtra College of pharmacy Nilanga, India
  • Hemant Nanasaheb Kale  Dr. Babasaheb Ambedkar Technological University, Lonere, Maharashtra, India
  • Sujata Bhati  Sharda University, Greater Noida, India
  • Vishal Sharma  Sharda University, Greater Noida, India

Keywords:

Maraviroc , Mucoadhesion , Iontopic Gelatin , Microspheres And Sodium Alginate

Abstract

Objective: Maraviroc is a small-molecule drug that inhibits HIV-1 access through blockading the interplay among HIV-1 and the chemokine receptor CCR5 on host cells. Maraviroc through Ionotropic gelation approach through using sodium alginate as mucoadhesive polymer in diverse proportions for keeping the dosage shape continue to be in location of absorption site for prolonged time period to deal with HIV contamination and to keep away from first pass metabolism. Maraviroc is an antiretroviral drug which can exactly manipulate viral load in HIV/AIDS patients. Maraviroc publicity is altered through sellers that modulate the interest of CYP3A4 and, in a few circumstances, maraviroc dose adjustment is necessary. Results - The optimal maraviroc microspheres had particles size of 434.82 um , Mucoadhesion of 93.3% and encapsulation efficiency 92.80% . The satisfactory batch F9 exhibited drug entrapment performance of 84.22%, and the drug launch from the microspheres become additionally sustained for extra than 10 hrs (96.48%). There have been no compatibility problems and the crystallinity of maraviroc drug become observed to be decreased in prepared maraviroc mucoadhesive microspheres, which have been showed via way of means of IR, DSC and XRD studies .The Stability of Maraviroc mucoadhesive microspheres become decided in 40°C/75% RH; it become observed that each Maraviroc and mucoadhesive microspheres have been strong in 40°C/75% RH for three months. Conclusion - The sodium alginate primarily based totally mucoadhesive microspheres have been organized through Ionotropic gelation technique for the managed release of maraviroc . Drug release observed the anomalous delivery and tremendous case-II delivery mechanism. Thus, it could be concluded that successfully designed to give controlled drug delivery, minimizing the drug related side effects and improved oral bioavailability.

References

  1. Kurana S, Madav NV.Review article on mucoadhesive drug Delivery; mechanism and method of evaluation. Int J Pharm BioSci 2011; 2 (1): 458-67.
  2. Yellanki SK, Singh J, Syed JA, Bigala R, Goranti S, Nerella NK. Design and characterization of amoxicillin Trihydrate Mucoadhesive microspheres for prolonged gastric retention. International journal of Pharmaceutical Sciences and Drug Research 2010; 2(2): 112-114.
  3. Chakraborty S, Dinda SC, -carbopol micropPatra N, Khandai M. Fabrication and Characterization of alginoarticulate system of aceclofenac for oral sustained drug delivery. Int J Pharm. Sci Rev Res 2010; 4(2): 192-199.
  4. Dhaliwal S, Jain S, Singh HP, Tiwary AK. Mucoadhesive microspheres for gastroretentive delivery of acyclovir: In Vitro and In Vivo evaluation. American Association of Pharmaceutical Scientists 2008; 10(2): 322-330.
  5. Talukder R, Fassihi R. Gastro-retentive drug delivery systems: A Mini Review. Drug Development and Industrial Pharmacy 2004; 30(10): 1019-1028.
  6. NK. Sachan, A Bhattacharya. Basics and Therapeutic potential of oral mucoadhesive microparticulate drug delivery systems. International Journal of Pharmaceutical and Clinical Research 2009; 1: 10-14.
  7. CP Rama kora, SY Arraguntla Rao. Mucoadhesive microspheres For controlled drug delivery. Biol Pharm Bull 2004; 27(11):1717-1724.
  8. Kalyankar TM. Formulation and evaluation of mucoadhesive Pioglitazone HCL microspheres. Int J Pharma World Res 2010; 1(3): 1-14.
  9. Vandekerckhove L, Verhofstede C, Vogelaers D. Maraviroc: inte Gration of a new antiretroviral drug class into clinical practice.Journal of Antimicrobial Chemotherapy 2008; 61: 1187-1190.
  10. MacArthur RD, Novak RM. Reviews of anti-infective agents: Maraviroc: the first of a new class of antiretroviral agents. Clin Infect Dis 2008; 47: 236-241.
  11. Carter NJ, Keating GM: Maraviroc. Drugs 2007; 67: 2277-2290.
  12. Samantha abel,David J back and Manoli vourvahis. Maraviroc: pharmacokinetics and drug interactions. Antiviral therapy 2009; 14:607-618.
  13. Soni, M.L., M. Kumar, M., and Namdeo, K.P. Sodium alginate microspheres for extending drug release: formulation and in vitro Evaluation. International Journal of Drug Delivery 2010; 2: 64-68.
  14. Manjanna, K.M., Shivakumar, B., and Kumar, P. Formulation of oral Sustained release aceclofenac sodium microbeads. International Journal of PharmTech Research 2009; 1: 940-952.
  15. Prajapati, S.K., Tripathi, P., Ubaidulla, U., and Anand, V. Design and Development of Gliclazide Mucoadhesive Microcapsules: In Vitro and In Vivo Evaluation. AAPS PharmSci Tech 2008; 9: 224-230. 16. Lucinda-Silva, R.M., Salgadob, H.RN., and Evangelista, R.C. Alginate–chitosan systems: In vitro controlled release of triamcinolone and in vivo gastrointestinal transit. Carbohydrate Polymers 2010; 81(2):260-268. 17. Al-Kassas, R.S., Al-Gohary, O.M., and Al-Faadhel, M.M. Controlling of systemic absorption of gliclazide through incorporation into alginate beads. International Journal of Pharmaceutics 2007; 341:230- 237. 18. Prasant R, Amitava G, Udaya N. et al. Effect Of Method Of Preparation On Physical Properties And In Vitro Drug Release Profile Of Losartan Microspheres – A Comparative Study,International Journal of Pharmacy and Pharmaceutical Sciences 2009; 1(1): 108-118.
  16. Patel JK, Bodar MS, Amin, Patel MM. Formulation and optimization of mucoadhesive microspheres of metoclopramide. Indian J Pharm Sci 2004; 66(3): 300-5. 20. Lehr CM, Bouwstra JA, Schacht EH, Junginger HE. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. International Journal of Pharmaceutics 1992; 78:43-48.  21. Ahuja A and Khar RK. Ali J.,Mucoadhesive drug delivery system. Drug. Dev.Ind. Pharm. 1997; 23(5):489-515. 22. Yeole, P.G., Galgatee, U.C., Babla, I.B. and Nakhat, P.D. 2006. Design and evaluation of xanthan gum based sustained release matrix tablets of Diclofenac Na. Indian J. Pharm.Sci 2006; 68:185-189.
  17. Chowdary KPR and Srinivas L., Mucoadhesive drug delivery systems: A review of current status. Indian Drugs. 2000; 37(9): 400-406. 24. SM Setter, L Jason, J Thams, RK Campbell. Metformin Hydrochloride in the Treatment of Type 2 Diabetes Mellitus; A clinical review with a focus on dual therapy. Clinical Therapeutics 2003; 25(12):2991-3026. 25. VTA Ibrahm, B senthil kumar , KG Parthiban, R. Manivannan. Novel drug delivery system ; formulation and characterization of exemestane microspheres by chemical cross linking method , Res J Pharm Biol Chem Sci 2010;1(4):83-90. 26. Arya RKK, Juyal V, Singh RD. Development and Evaluation of Gastro resistant Microsphere of Pantoprazole. International Journal of Pharmacy and Pharmaceutical Sciences 2010; 2(3): 112-16.  27. Kavitha.K, Chintagunta pavanveena, Anil kumar.S.N, Tamizh mani.T. Formulation and evaluation of trimetazidine hydrochloride loaded gelatin microspheres. International Journal of Pharmacy and Pharmaceutical Sciences 2010; 2(3): 67-70.
  18. Shah P, Rajshree M, Rane Y. Stability testing of pharmaceuticals - A global perspective. Journal of Pharmacy Research 2007; 6(1):1-9. 29. Rastogi, R., Sultana, Y., Aqil, M., Ali, A., Kumar, S.,N Chuttani, K., and Mishra, A.K. Alginate microspheres of isoniazid for oral sustained drug delivery. International Journal of Pharmaceutics 2007; 334: 71-77. 30. Shankar, N.B., Kumar, N.U., and Balakrishna, P.K. Formulation Design, Preparation and In vitro Evaluation of Mucoadhesive Microcapsule employing control release Polymers to enhance gastro retention for Oral delivery of Famotidine. Int J Pharm SciTech 2009; 2: 22-29. 31. Chen, L., and Subirade, M. Alginate–whey protein granular microspheres as oral delivery vehicles for bioactive compounds. Biomaterials 2006; 27:4646-4654. 32. Silva, C.M., Ribeiro, A.J., Figueiredo, M., Ferreira, D., and Veiga, F. Microencapsulation of Hemoglobin in Chitosan-coated Alginate Microspheres Prepared by Emulsification/Internal Gelation. The AAPS Journal 2006; 7: 903-913.

International Journal of Scientific Research in Science and Technology

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Published

2022-04-30

Issue

Volume 9, Issue 2, March-April-2022

Section

Research Articles

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[1]
Mr. Saurabh Jawahar Sanghavi, Sharad Verma, Adarsh Raj, Gore Avinash Bharat, Budhe Vaishnavi Jaykumar, Hemant Nanasaheb Kale, Sujata Bhati, Vishal Sharma "Formulation, Development and Evaluation of Anti-Viral Microspheres Using Ionotopic Gelatin Method " International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011,Volume 9, Issue 2, pp.315-317, March-April-2022.